TOPMed and TOPMed related datasets

The BioData Catalyst ecosystem hosts several datasets from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. The PIC-SURE platform has integrated the clinical and genomic data from all studies listed in the Data Access Dashboard. Through the ingestion process, occasionally PIC-SURE will ingest phenotypic data for the TOPMed studies prior to the genomic data.

Harmonized Data (TOPMed Harmonized Clinical Variables)

There are limited amounts of harmonized data available at this time. The TOPMed Data Coordinating Center (DCC) curation team has identified 44 variables that are shared across 17 NHLBI studies and normalized the participant values for these variables.

The 44 harmonized variables available are listed in the table in Appendix 2. For more information on this initiative, you can view the additional documentation from the TOPMed DCC GitHub repository or on the NHLBI Trans-Omics for Precision Medicine website.

Table of Studies Included in the TOPMed Harmonized Dataset Available in PIC-SURE

Atherosclerosis Risk in Communities Study	ARIC	phs000280
Cardiovascular Health Study	CHS	phs000287
Cleveland Family Study	CFS	phs000284
Coronary Artery Risk Development in Young Adults Study	CARDIA	phs000285
Epidemiology of Asthma in Costa Rica Study	CRA	phs000988
Framingham Heart Study	FHS	phs000007
Genetic Epidemiology Network of Arteriopathy	GENOA	phs001238
Genetic Epidemiology of COPD	COPDGene	phs000179
Genetics of Cardiometabolic Health in Amish	AMISH	phs000956
Genome-Wide Association Study of Venous Thrombosis Study	MAYOVTE	phs000289
Heart and Vascular Health Study	HVH	phs001013
Hispanic Community Health Study - Study of Latinos	HCHS-SOL	phs000810
Jackson Heart Study	JHS	phs000286
Multi-Ethnic Study of Atherosclerosis	MESA	phs000209
Study of Adiposity in Samoans	SAS	phs000914
Women’s Health Initiative WHI	WHI	phs000200