# TOPMed and TOPMed related datasets

The BDC ecosystem hosts several datasets from the [NHLBI Trans-Omics for Precision Medicine (TOPMed) program](https://topmed.nhlbi.nih.gov/). The PIC-SURE platform has integrated the clinical and genomic data from all studies listed in the Data Access Dashboard. _Through the ingestion process, occasionally PIC-SURE will ingest phenotypic data for the TOPMed studies prior to the genomic data._

## **Harmonized Data (TOPMed Harmonized Clinical Variables)**

There are limited amounts of harmonized data available at this time. The TOPMed Data Coordinating Center (DCC) curation team has identified 44 variables that are shared across 17 NHLBI studies and normalized the participant values for these variables.

The 44 harmonized variables available are listed in the table in Appendix 2. For more information on this initiative, you can view the [additional documentation from the TOPMed DCC GitHub repository](https://github.com/UW-GAC/topmed-dcc-harmonized-phenotypes) or on the [NHLBI Trans-Omics for Precision Medicine website](https://topmed.nhlbi.nih.gov/dcc-harmonized-phenotypes).

## Table of Studies Included in the TOPMed Harmonized Dataset Available in PIC-SURE

| Atherosclerosis Risk in Communities Study                | ARIC     | phs000280 |
| -------------------------------------------------------- | -------- | --------- |
| Cardiovascular Health Study                              | CHS      | phs000287 |
| Cleveland Family Study                                   | CFS      | phs000284 |
| Coronary Artery Risk Development in Young Adults Study   | CARDIA   | phs000285 |
| Epidemiology of Asthma in Costa Rica Study               | CRA      | phs000988 |
| Framingham Heart Study                                   | FHS      | phs000007 |
| Genetic Epidemiology Network of Arteriopathy             | GENOA    | phs001238 |
| Genetic Epidemiology of COPD                             | COPDGene | phs000179 |
| Genetics of Cardiometabolic Health in Amish              | AMISH    | phs000956 |
| Genome-Wide Association Study of Venous Thrombosis Study | MAYOVTE  | phs000289 |
| Heart and Vascular Health Study                          | HVH      | phs001013 |
| Hispanic Community Health Study - Study of Latinos       | HCHS-SOL | phs000810 |
| Jackson Heart Study                                      | JHS      | phs000286 |
| Multi-Ethnic Study of Atherosclerosis                    | MESA     | phs000209 |
| Study of Adiposity in Samoans                            | SAS      | phs000914 |
| Women’s Health Initiative WHI                            | WHI      | phs000200 |
