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  • Introduction
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  1. Written Documentation
  2. Release Notes

2024-01-08 NHLBI BioData Catalyst Ecosystem Release Notes

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Last updated 1 year ago

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Introduction

The 2024-01-08 release marks the 16th release for the NHLBI BioData Catalyst® (BDC) ecosystem. This release includes several new features (e.g., enabling Azure and searching data without logging in) along with documentation and tutorials (e.g., data dictionary field documentation) to help new users get started on the system. Please find more detail on the new features and user support materials in the sections below.

The 2024-01-08 data releases include the addition of research on multisystem inflammatory syndrome in children linked to COVID-19, bone marrow transplant and pulmonary hypertension in sickle cell disease, atherosclerosis, and psoriasis. Please refer to the Data Releases section below for more information as well as the on the BDC website.

Significant new features

Azure available on BDC Powered by Seven Bridges (BDC-SB): Velsera expanded their existing multi-cloud offerings by enabling Microsoft Azure (southcentralus) on BDC-SB. Users can select that computing and storage environment when creating a project. This allows users to avoid any egress charges when computing on data stored in Azure. This is of particular interest to users who want to connect their own Azure cloud buckets to BDC-SB.

SAS upgrade in BDC-SB: SAS on BDC-SB has been upgraded from SAS Viya 3.5 to SAS Studio 9.4. SAS 9.4 has improved functionality over SAS 3.5 including more complete data management solutions and additional programming languages.

Open PIC-SURE without login: Open PIC-SURE is now publicly available on BDC Powered by PIC-SURE (BDC-PIC-SURE), meaning no eRA Commons credentials are required to access the site. Researchers can access this site to search terms of interest, apply filters at the variable-value level, retrieve obfuscated, aggregate counts, and view single variable distributions of their selected cohort. This new functionality allows researchers to discover and interact with data available on BDC without needing to log in, decreasing the barrier to data exploration. Check out Open PIC-SURE .

Data Hierarchies in BDC-PIC-SURE: Researchers are now able to view the data hierarchy associated with variables in BDC-PIC-SURE by clicking the “Data Tree” icon in the “Actions” column of the search results. This enables researchers to understand better how variables are related and obtain additional context for these variables. Note that this feature is currently in beta and will only be available for some studies. Feedback and input on this feature is welcome!

New user support materials and documentation

BDC-PIC-SURE Data Dictionary fields documentation: Documentation outlining the data dictionary fields returned from the PIC-SURE API was created. This provides a detailed account of what each field represents, including relationships between fields. This documentation can be found in the BDC-PIC-SURE GitBook .

Data Releases

The table below highlights which studies were included in the 2024-01-08 data release. The release features research on long-term outcomes of multisystem inflammatory syndrome in children linked to COVID-19 (COVID19-MUSIC_GRU), bone marrow transplant for severe sickle cell disease (BioLINCC-BMT_CTN_HMB), and ApoA-1, atherosclerosis, and psoriasis (DIR-ApoA-1_Atherosclerosis_in_Psoriasis_GRU). Additionally, updated metadata is provided for the ongoing study on sildenafil therapy in treating pulmonary hypertension in sickle cell disease (walk-PHaSST). This data includes clinical files and is now available for access. The data is now available for access across the entire ecosystem.

Study Name
phs I.D. #
Acronym
New to BioData Catalyst
New study version

Long-TerM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC)

phs002770.v1.p1.c1

COVID19-MUSIC_GRU

Yes

Yes

Unrelated Donor Reduced Intensity Bone Marrow Transplant for Children with Severe Sickle Cell Disease (BMT CTN-0601-BioLINCC)

phs003470.v1.p1.c1

BioLINCC-BMT_CTN_HMB

Yes

Yes

ApoA-1 and Atherosclerosis in Psoriasis (DIR)

phs003231.v1.p1.c1

DIR-ApoA-1_Atherosclerosis_in_Psoriasis_GRU

Yes

Yes

Treatment of Pulmonary Hypertension and Sickle Cell Disease With Sildenafil Therapy (walk-PHaSST)

phs002383.v1.p1.c1

BioLINCC-Walk_PHaSST_DS-SCD-IRB-PUB-COL-NPU-MDS-RD

No

No

Planned Upcoming Data Releases

Study Name
phs I.D. #
Acronym
New to BioData Catalyst
New study version

Genetic Epidemiology of COPD Study (COPDGene)

phs002910.v1.p1.c1

COVID19-C4R_COPDGene_HMB

Yes

Yes

Genetic Epidemiology of COPD Study (COPDGene)

phs002910.v1.p1.c2

COVID19-C4R_COPDGene_DS-CS

Yes

Yes

The Mediators of Atherosclerosis in South Asians Living in America (MASALA)

phs002980.v1.p1.c1

COVID19-C4R_MASALA_HMB-IRB-COL

Yes

Yes

Prevent Pulmonary Fibrosis (PrePF)

phs002975.v1.p1.c1

COVID19-C4R_PrePF_HMB

Yes

Yes

A Multi-site Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults (RECOVER)

phs003463.v1.p1.c1

RECOVER-Adult

Yes

Yes

Hispanic Community Health Study (HCHS)

phs003457.v1.p1.c1

NSRR-HCHS

Yes

Yes

Hispanic Community Health Study (HCHS)

phs003457.v1.p1.c2

NSRR-HCHS

Yes

Yes

NHLBI TOPMed: The Genetic Epidemiology of Asthma in Costa Rica (CRA)

phs000988.v5.p1.c1

topmed-CRA_DS-ASTHMA-IRB-MDS-RD

No

Yes

NHLBI TOPMed - NHGRI CCDG: Genes-Environments and Admixture in Latino Asthmatics (GALA II)

phs000920.v5.p2.c2

topmed-GALAII_DS-LD-IRB-COL

No

Yes

NHLBI TOPMed: HyperGEN - Genetics of Left Ventricular (LV) Hypertrophy

phs001293.v3.p1.c1

topmed-HyperGEN_GRU-IRB

No

Yes

NHLBI TOPMed: HyperGEN - Genetics of Left Ventricular (LV) Hypertrophy

phs001293.v3.p1.c2

HyperGEN_DS-CVD-IRB-RD

No

Yes

NHLBI TOPMed: Whole Genome Sequencing of Venous Thromboembolism (WGS of VTE)

phs001402.v3.p1.c1

Mayo_VTE_GRU

No

Yes

NHLBI TOPMed - NHGRI CCDG: Massachusetts General Hospital (MGH) Atrial Fibrillation Study

phs001062.v5.p2.c2

MGH_AF_DS-AF-IRB-RD

No

Yes

NHLBI TOPMed - NHGRI CCDG: Massachusetts General Hospital (MGH) Atrial Fibrillation Study

phs001062.v5.p2.c1

MGH_AF_HMB-IRB

No

Yes

NHLBI TOPMed: African American Sarcoidosis Genetics Resource

phs001207.v3.p1.c1

Sarcoidosis_DS-SAR-IRB

No

Yes

NHLBI TOPMed: Women's Health Initiative (WHI)

phs001237.v3.p1.c1

WHI_HMB-IRB

No

Yes

NHLBI TOPMed: Women's Health Initiative (WHI)

phs001237.v3.p1.c2

WHI_HMB-IRB-NPU

No

Yes

NHLBI TOPMed - NHGRI CCDG: Atherosclerosis Risk in Communities (ARIC)

phs001211.v4.p2.c2

ARIC_DS-CVD-IRB

No

Yes

NHLBI TOPMed - NHGRI CCDG: Atherosclerosis Risk in Communities (ARIC)

phs001211.v4.p2.c1

ARIC_HMB-IRB

No

Yes

NHLBI TOPMed: Genetics of Cardiometabolic Health in the Amish

phs000956.v5.p1.c2

Amish_HMB-IRB-MDS

No

Yes

NHLBI TOPMed: Australian Familial Atrial Fibrillation Study

phs001435.v2.p1.c1

AustralianFamilialAF_HMB-NPU-MDS

No

Yes

NHLBI TOPMed - NHGRI CCDG: Early-onset Atrial Fibrillation in the CATHeterization GENetics (CATHGEN) Cohort

phs001600.v3.p2.c1

CATHGEN_DS-CVD-IRB

No

Yes

NHLBI TOPMed: Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE)

phs001472.v2.p1.c1

ECLIPSE_DS-COPD-MDS-RD

No

Yes

NHLBI TOPMed: Genetic Epidemiology Network of Arteriopathy (GENOA)

phs001345.v3.p1.c1

GENOA_DS-ASC-RF-NPU

No

Yes

NHLBI TOPMed: Genetic Epidemiology Network of Salt Sensitivity (GenSalt)

phs001217.v3.p1.c1

GenSalt_DS-HCR-IRB

No

Yes

NHLBI TOPMed: GOLDN Epigenetic Determinants of Lipid Response to Dietary Fat and Fenofibrate

phs001359.v3.p1.c1

GOLDN_DS-CVD-IRB

No

Yes

NHLBI TOPMed: Defining the time-dependent genetic and transcriptomic responses to cardiac injury among patients with arrhythmias

phs001434.v2.p1.c1

miRhythm_GRU

No

Yes

NHLBI TOPMed: Partners HealthCare Biobank

phs001024.v5.p1.c1

PARTNERS_HMB

No

Yes

NHLBI TOPMed: Pharmacogenomics of Hydroxyurea in Sickle Cell Disease (PharmHU)

phs001466.v2.p1.c3

pharmHU_DS-SCD

No

Yes

NHLBI TOPMed: Pharmacogenomics of Hydroxyurea in Sickle Cell Disease (PharmHU)

phs001466.v2.p1.c2

pharmHU_DS-SCD-RD

No

Yes

NHLBI TOPMed: Pharmacogenomics of Hydroxyurea in Sickle Cell Disease (PharmHU)

phs001466.v2.p1.c1

pharmHU_HMB

No

Yes

NHLBI TOPMed: REDS-III Brazil Sickle Cell Disease Cohort (REDS-BSCDC)

phs001468.v3.p1.c1

REDS-III_Brazil_SCD_GRU-IRB-PUB-NPU

No

Yes

NHLBI TOPMed: San Antonio Family Heart Study (SAFHS)

phs001215.v4.p2.c1

SAFHS_DS-DHD-IRB-PUB-MDS-RD

No

Yes

NHLBI TOPMed: Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE)

phs001467.v2.p1.c1

SAPPHIRE_asthma_DS-ASTHMA-IRB-COL

No

Yes

NHLBI TOPMed: Novel Risk Factors for the Development of Atrial Fibrillation in Women

phs001040.v5.p1.c1

WGHS_HMB

No

Yes

For detailed platform release notes please consult the following resources:

BDC-Gen3 release notes

Data page
here
here
BDC-Terra release notes
BDC-Seven Bridges release notes
BDC-PIC-SURE release notes