2024-04-01 NHLBI BioData Catalyst Ecosystem Release Notes
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The 2024-04-01 release marks the 17th release for the NHLBI BioData Catalyst® (BDC) ecosystem. This release includes several new features (e.g., SRA import via DRS and the ability to save dataset IDs). Please find more details on the new features below.
The 2024-04-01 data releases include the addition of research on heart failure and COVID-19 plus version updates to ongoing genetic and genomic studies including COPD and atrial fibrillation. Please refer to the Data Releases section below for more information as well as the on the BDC website.
BDC Powered by Seven Bridges (BDC-Seven Bridges) SRA Import via DRS: The Sequence Read Archive (SRA) has been accessible via the SRA Toolkit, which involves users downloading a copy to their local environment and then downloading the SRA data to their project on BDC-Seven Bridges. NCBI is now storing the SRA data in cloud buckets on Amazon and Google, allowing users to avoid egress charges and simplifying access to the data via BDC-Seven Bridges’ new .
BDC Powered by PIC-SURE Save Dataset ID: Users can now save the dataset ID after applying filters and building a cohort, allowing them to view and access their saved cohorts at a later time. Saved dataset IDs can be viewed and managed on the Dataset Management page.
The table below highlights which studies were included in the 2024-04-01 data release.
The latest release incorporates studies from the Heart Failure Network (HFN), National Sleep Research Resource (NSRR), Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection (RECOVER Adult), and the Collaborative Cohort of Cohorts for COVID-19 Research (C4R). Additionally, the release broadens its scope with version updates to ongoing genetic and genomic studies, including the NHLBI TOPMed projects such as the evaluation of COPD longitudinally, and the genetic epidemiology of conditions like atrial fibrillation within the CATHGEN cohort, among others.
The data will be available for access across the entire ecosystem by 2024-04-05.
Heart Failure Network: Diuretic Optimization Strategies Evaluation in Acute Heart Failure (HFN DOSE-BioLINCC)
phs003524.v1.p1.c1
BioLINCC-BL_HFN_DOSE_AHF_GRU
Yes
No
National Sleep Research Resource (NSRR): Hispanic Community Health Study/Study of Latinos
phs003543.v1.p1.c1
NSRR-HCHS_HMB-NPU
Yes
No
National Sleep Research Resource (NSRR): Hispanic Community Health Study/Study of Latinos
phs003543.v1.p1.c2
NSRR-HCHS_HMB
Yes
No
NIH RECOVER: A Multi-Site Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults
phs003463.v1.p1.c1
RECOVER-RC_Adult_GRU
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Prevent Pulmonary Fibrosis (PrePF)
phs002975.v1.p1.c1
COVID19-C4R_PREPF_DS-PMD-IRB
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Genetic Epidemiology of COPD Study (COPDGene)
phs002910.v1.p1.c2
COVID19-C4R_COPDGENE_DS-CS
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Genetic Epidemiology of COPD Study (COPDGene)
phs002910.v1.p1.c1
COVID19-C4R_COPDGENE_HMB
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Multi-Ethnic Study of Atherosclerosis (MESA)
phs003017.v1.p1.c1
COVID19-C4R_MESA_HMB
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Multi-Ethnic Study of Atherosclerosis (MESA)
phs003017.v1.p1.c2
COVID19-C4R_MESA_HMB-NPU
Yes
No
NHLBI TOPMed: Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE)
phs001472.v2.p1.c1
topmed-ECLIPSE_DS-COPD-MDS-RD
No
Yes
NHGRI CCDG: Early-onset Atrial Fibrillation in the CATHeterization GENetics (CATHGEN) Cohort
phs001600.v3.p2.c1
topmed-CATHGEN_DS-CVD-IRB
No
Yes
NHLBI TOPMed: Genetic Epidemiology Network of Arteriopathy (GENOA)
phs001345.v3.p1.c1
topmed-GENOA_DS-ASC-RF-NPU
No
Yes
NHLBI TOPMed: Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)
phs001359.v3.p1.c1
topmed-GOLDN_DS-CVD-IRB
No
Yes
NHLBI TOPMed: University of Massachusetts Medical School (UMMS) miRhythm Study
phs001434.v2.p1.c1
topmed-miRhythm_GRU
No
Yes
NHLBI TOPMed: Genetics of Cardiometabolic Health in the Amish
phs000956.v4.p1.c2
topmed-Amish_HMB-IRB-MDS
No
Yes
NHLBI TOPMed: Genetic Epidemiology of COPD (COPDGene) in the TOPMed Program
phs000951.v5.p4.c1
topmed-COPDGene_HMB
No
Yes
NHLBI TOPMed: Genetic Epidemiology of COPD (COPDGene) in the TOPMed Program
phs000951.v5.p4.c2
topmed-COPDGene_DS-CS-RD
No
Yes
NHLBI TOPMed: Trans-Omics for Precision Medicine Whole Genome Sequencing Project: ARIC
phs001211.v4.p2.c1
topmed-ARIC_HMB-IRB
No
Yes
NHLBI TOPMed: Trans-Omics for Precision Medicine Whole Genome Sequencing Project: ARIC
phs001211.v4.p2.c2
topmed-ARIC_DS-CVD-IRB
No
Yes
NHLBI TOPMed: REDS-III Brazil Sickle Cell Disease Cohort (REDS-BSCDC)
phs001468.v3.p1.c1
topmed-REDS-III_Brazil_SCD_GRU-IRB-PUB-NPU
No
Yes
NHLBI TOPMed: The Genetic Epidemiology of Asthma in Costa Rica
phs000988.v5.p1.c1
topmed-CRA_DS-ASTHMA-IRB-MDS-RD
No
Yes
NHLBI TOPMed: Genes-environments and Admixture in Latino Asthmatics (GALA II) Study
phs000920.v5.p2.c2
topmed-GALAII_DS-LD-IRB-COL
No
Yes
LungMAP: Molecular Atlas of Lung Development - Human Lung Tissue
phs001961.v2.p1.c1
LungMAP-MALD_GRU
No
No
Unrelated Donor Reduced Intensity Bone Marrow Transplant for Children with Severe Sickle Cell Disease (BMT CTN-0601-BioLINCC)
phs003470.v1.p1.c1
BioLINCC-BMT_CTN-0601_GRU
No
No
NHLBI TOPMed: HyperGEN - Genetics of Left Ventricular (LV) Hypertrophy
phs001293.v3.p1.c2
topmed-HyperGEN_DS-CVD-IRB-RD
No
Yes
NHLBI TOPMed - NHGRI CCDG: AF Biobank LMU in the context of the MED Biobank LMU
phs001543.v2.p1.c1
topmed-AFLMU_HMB-IRB-PUB-COL-NPU-MDS
No
Yes
NHLBI TOPMed: Australian Familial Atrial Fibrillation Study
phs001435.v2.p1.c1
topmed-AustralianFamilialAF_HMB-NPU-MDS
No
Yes
NHLBI TOPMed - NHGRI CCDG: Penn Medicine BioBank Early Onset Atrial Fibrillation Study
phs001601.v2.p1.c1
topmed-CCDG_PMBB_AF_HMB-IRB-PUB
No
Yes
NHLBI TOPMed: Children's Health Study (CHS) Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma (GAP)
phs001602.v2.p1.c1
topmed-ChildrensHS_GAP_GRU
No
Yes
NHLBI TOPMed: Children's Health Study (CHS) Integrative Genomics and Environmental Research of Asthma (IGERA)
phs001603.v2.p1.c1
topmed-ChildrensHS_IGERA_GRU
No
Yes
NHLBI TOPMed: Children's Health Study (CHS) Effects of Air Pollution on the Development of Obesity in Children (Meta-AIR)
phs001604.v2.p1.c1
topmed-ChildrensHS_MetaAir_GRU
No
Yes
NHLBI TOPMed: Chicago Initiative to Raise Asthma Health Equity (CHIRAH)
phs001605.v2.p1.c2
topmed-CHIRAH_DS-ASTHMA-IRB-COL
No
Yes
NHLBI TOPMed: Determining the association of chromosomal variants with non-PV triggers and ablation-outcome in AF (DECAF)
phs001546.v2.p1.c1
topmed-DECAF_GRU
No
Yes
NHLBI TOPMed: Early-onset Atrial Fibrillation in the Estonian Biobank
phs001606.v2.p1.c1
topmed-EGCUT_GRU
No
Yes
NHLBI TOPMed: Genetics of Asthma in Latino Americans (GALA)
phs001542.v2.p1.c2
topmed-GALA_DS-LD-IRB-COL
No
Yes
NHLBI TOPMed: Pharmacogenomics of Hydroxyurea in Sickle Cell Disease (PharmHU)
phs001466.v2.p1.c3
topmed-pharmHU_DS-SCD
No
Yes
NHLBI TOPMed: Pharmacogenomics of Hydroxyurea in Sickle Cell Disease (PharmHU)
phs001466.v2.p1.c2
topmed-pharmHU_DS-SCD-RD
No
Yes
NHLBI TOPMed - NHGRI CCDG: The GENetics in Atrial Fibrillation (GENAF) Study
phs001547.v2.p1.c1
topmed-GENAF_HMB-NPU
No
Yes
NHLBI TOPMed: Genetic Study of Atherosclerosis Risk (GeneSTAR)
phs001218.v3.p1.c2
topmed-GeneSTAR_DS-CVD-IRB-NPU-MDS
No
Yes
NHLBI TOPMed: Genetic Epidemiology Network of Salt Sensitivity (GenSalt)
phs001217.v3.p1.c1
topmed-GenSalt_DS-HCR-IRB
No
Yes
NHLBI TOPMed - NHGRI CCDG: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
phs001395.v2.p1.c2
topmed-HCHS-SOL_HMB
No
Yes
NHLBI TOPMed - NHGRI CCDG: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
phs001395.v2.p1.c1
topmed-HCHS-SOL_HMB-NPU
No
Yes
NHLBI TOPMed: HyperGEN - Genetics of Left Ventricular (LV) Hypertrophy
phs001293.v3.p1.c1
topmed-HyperGEN_GRU-IRB
No
Yes
NHLBI TOPMed - NHGRI CCDG: Intermountain INSPIRE Registry
phs001545.v2.p1.c1
topmed-INSPIRE_AF_DS-MULTIPLE_DISEASES-MDS
No
Yes
NHLBI TOPMed - NHGRI CCDG: The Johns Hopkins University School of Medicine Atrial Fibrillation Genetics Study
phs001598.v2.p1.c1
topmed-JHU_AF_HMB-NPU-MDS
No
Yes
NHLBI TOPMed: Whole Genome Sequencing of Venous Thromboembolism (WGS of VTE)
phs001402.v3.p1.c1
topmed-Mayo_VTE_GRU
No
Yes
NHLBI TOPMed - NHGRI CCDG: Massachusetts General Hospital (MGH) Atrial Fibrillation Study
phs001062.v5.p2.c2
topmed-MGH_AF_DS-AF-IRB-RD
No
Yes
NHLBI TOPMed - NHGRI CCDG: Massachusetts General Hospital (MGH) Atrial Fibrillation Study
phs001062.v5.p2.c1
topmed-MGH_AF_HMB-IRB
No
Yes
NHLBI TOPMed: MyLifeOurFuture (MLOF) Research Repository of patients with hemophilia A (factor VIII deficiency) or hemophilia B (factor IX deficiency)
phs001515.v2.p1.c1
topmed-MLOF_HMB-PUB
No
Yes
NHLBI TOPMed - NHGRI CCDG: Malmo Preventive Project (MPP)
phs001544.v2.p1.c1
topmed-MPP_HMB-NPU-MDS
No
Yes
NHLBI TOPMed: Partners HealthCare Biobank
phs001024.v5.p1.c1
topmed-PARTNERS_HMB
No
Yes
NHLBI TOPMed: Pharmacogenomics of Hydroxyurea in Sickle Cell Disease (PharmHU)
phs001466.v2.p1.c1
topmed-pharmHU_HMB
No
Yes
NHLBI TOPMed: San Antonio Family Heart Study (SAFHS)
phs001215.v4.p2.c1
topmed-SAFHS_DS-DHD-IRB-PUB-MDS-RD
No
Yes
NHLBI TOPMed: Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE)
phs001467.v2.p1.c1
topmed-SAPPHIRE_asthma_DS-ASTHMA-IRB-COL
No
Yes
NHLBI TOPMed: African American Sarcoidosis Genetics Resource
phs001207.v3.p1.c1
topmed-Sarcoidosis_DS-SAR-IRB
No
Yes
NHLBI TOPMed: Genome-Wide Association Study of Adiposity in Samoans
phs000972.v5.p1.c1
topmed-SAS_GRU-IRB-PUB-COL-NPU-GSO
No
Yes
NHLBI TOPMed: Rare Variants for Hypertension in Taiwan Chinese (THRV)
phs001387.v3.p1.c3
topmed-THRV_DS-CVD-IRB-COL-NPU-RD
No
Yes
NHLBI TOPMed: Novel Risk Factors for the Development of Atrial Fibrillation in Women
phs001040.v5.p1.c1
topmed-WGHS_HMB
No
Yes
NHLBI TOPMed: Women's Health Initiative (WHI)
phs001237.v3.p1.c1
topmed-WHI_HMB-IRB
No
Yes
NHLBI TOPMed: Women's Health Initiative (WHI)
phs001237.v3.p1.c2
topmed-WHI_HMB-IRB-NPU
No
Yes
BDC-Gen3 release notes