2025-01-15 NHLBI BioData Catalyst Ecosystem Release Notes
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The 2025-01-15 release marks the 20th release for the NHLBI BioData Catalyst® (BDC) ecosystem. This release includes several new features (e.g., storage cost savings and PFB handoff of cohort data) along with documentation and tutorials (e.g., video guides to BDC Data Studio environments) to help new users get started on the system. This release also includes enhanced support for working with cohort data. Please find more detail on the new features and user support materials in the sections below.
The 2025-01-15 data releases include the addition of studies on pulmonary fibrosis, COPD, asthma, and congenital heart defects, along with new imaging from atherosclerosis and echocardiogram studies. Updates also include research on cardiovascular health, genetic epidemiology, COVID-19, blood pressure, veteran health, and lifestyle interventions. Please refer to the Data Releases section below for more information as well as the on the BDC website.
Save on storage costs in Terra with bucket lifecycle rules: This feature on BDC Powered by Terra (BDC-Terra) gives users better controls to delete unnecessary workspace bucket files and manage cloud storage costs.
PFB Handoff of Cohort Data from PIC-SURE to Terra: After exploring data and adding filters to build a cohort of interest in BDC Powered by PIC-SURE (BDC-PIC-SURE), investigators can now seamlessly move the participant-level data to BDC-Terra for analysis. This feature allows investigators to bring the data into a new or previously existing BDC-Terra workspace using the Portable Format for Bioinformatics, or PFB, format. This format includes two tables: the participant-level data and the associated data dictionary. and at .
Links to Original Files from Selected Cohort Data: The selected participant-level data from BDC-PIC-SURE is now connected back to the original data file. The data is connected using DRS URIs, a GA4GH standard used to allow access to data in a single, standard way. This allows investigators to refer back to the original source of the BDC-PIC-SURE data. This feature is currently available in the data dictionary table with the PFB formatted BDC-PIC-SURE data. Note: This is currently available for some studies, but the DRS URIs of other studies are being added regularly.
Connect Cohort Data to Genomic Information via Sample Identifiers: Investigators can automatically include sample identifiers when preparing selected cohort data for analysis in BDC-PIC-SURE. The sample identifiers allow researchers to connect the phenotypic information to the associated genomic data or other sample types.
Explore Data with Social Determinants of Health (SDOH) Gravity Domains: Several variables from BDC data have been mapped to SDOH domains from the Gravity Project, a collaborative public-private initiative with the goal of developing consensus-driven data standards to support the collection, use, and exchange of data to address SDOH. These mappings can be used to explore the data in BDC-PIC-SURE.
Video guides to BDC Data Studio Environments: Three new onboarding videos were created to introduce and orient users to the three kinds of Data Studio environments available on BDC: JupyterLab, RStudio, and SAS Studio. These videos are available on the as platform-generated videos.
The table below highlights which studies were included in the 2025-01-15 data release.
The latest release features NHLBI TOPMed projects, including the San Antonio Family Heart Study (SAFHS), Women's Health Initiative (WHI), and the Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Project, with updates from the Cardiovascular Health Study (CHS). New additions include the study of African Americans, Asthma, Genes, and Environment (SAGE), the Pulmonary Fibrosis Whole Genome Sequencing project, and the Genetic Epidemiology of COPD (COPDGene). Furthermore, the release highlights studies on the Molecular Genetics of Heterotaxy and Related Congenital Heart Defects, and the Collaborative Cohort of Cohorts for COVID-19 Research (C4R) with data from SPIROMICS and Jackson Heart Study (JHS). Featured are several BioLINCC studies, such as the Systolic Blood Pressure Intervention Trial (SPRINT), Heart Failure Network studies, and the Resuscitation Outcomes Consortium (ROC). This release introduces the Multi-Ethnic Study of Atherosclerosis (MESA) Echocardiogram Image Repository and includes data from the Veterans Administration (VA) Million Veteran Program (MVP) as well as the Healthy Lifestyle Program (HeLP).
The data is now available for access across the entire ecosystem.
NHLBI TOPMed: San Antonio Family Heart Study (SAFHS)
phs001215.v4.p2.c1
topmed-SAFHS_DS-DHD-IRB-PUB-MDS-RD
No
Yes
NHLBI TOPMed: Women's Health Initiative (WHI)
phs001237.v3.p1.c1
topmed-WHI_HMB-IRB
No
Yes
NHLBI TOPMed: Women's Health Initiative (WHI)
phs001237.v3.p1.c2
topmed-WHI_HMB-IRB-NPU
No
Yes
NHLBI TOPMed: Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Project: Cardiovascular Health Study
phs001368.v4.p2.c1
topmed-CHS_HMB-MDS
No
Yes
NHLBI TOPMed: Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Project: Cardiovascular Health Study
phs001368.v4.p2.c2
topmed-CHS_HMB-NPU-MDS
No
Yes
NHLBI TOPMed: Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Project: Cardiovascular Health Study
phs001368.v4.p2.c3
topmed-CHS_DS-CVD-MDS
Yes
No
NHLBI TOPMed: Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Project: Cardiovascular Health Study
phs001368.v4.p2.c4
topmed-CHS_DS-CVD-NPU-MDS
No
Yes
NHLBI TOPMed: Whole Genome Sequencing of Venous Thromboembolism (WGS of VTE)
phs001402.v3.p1.c1
topmed-Mayo_VTE_GRU
No
Yes
NHLBI TOPMed: My Life Our Future (MLOF) Research Repository of Patients with Hemophilia A (Factor VIII Deficiency) or Hemophilia B (Factor IX Deficiency)
phs001515.v2.p2.c1
topmed-MLOF_HMB-PUB
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v3.p2.c1
topmed-IPF_DS-ILD-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v3.p2.c2
topmed-IPF_DS-LD-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v3.p2.c3
topmed-IPF_DS-PFIB-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v3.p2.c4
topmed-IPF_DS-PUL-ILD-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v3.p2.c5
topmed-IPF_HMB-IRB-NPU
No
Yes
TRanscriptomic ANalySis of left ventriCulaR gene Expression (TRANSCRibE)
phs001679.v1.p1.c1
heartfailure-TRANSCRibE_GRU
Yes
No
TRanscriptomic ANalySis of left ventriCulaR gene Expression (TRANSCRibE)
phs001679.v1.p1.c2
heartfailure-TRANSCRibE_DS-CI
Yes
No
NHLBI TOPMed: Pediatric Cardiac Genomics Consortium (PCGC)'s Congenital Heart Disease Biobank
phs001735.v2.p1.c1
topmed-PCGC_CHD_HMB
No
No
NHLBI TOPMed: Pediatric Cardiac Genomics Consortium (PCGC)'s Congenital Heart Disease Biobank
phs001735.v2.p1.c2
topmed-PCGC_CHD_DS-CHD
No
No
Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
phs001814.v1.p1.c1
heartfailure-MolGen_CHD_GRU
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c1
COVID19-C4R_SPIROMICS_GRU
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c2
COVID19-C4R_SPIROMICS_GRU-NPU
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c3
COVID19-C4R_SPIROMICS_DS-COPD
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c4
COVID19-C4R_SPIROMICS_DS-COPD-NPU
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c5
COVID19-C4R_SPIROMICS_GRU-COL
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c6
COVID19-C4R_SPIROMICS_GRU-COL-NPU
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c7
COVID19-C4R_SPIROMICS_DS-COPD-COL
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
phs002909.v1.p1.c8
COVID19-C4R_SPIROMICS_DS-COPD-COL-NPU
No
No
Adult Observational Cohort Study (RC_Adult)
phs003463.v3.p2.c1
RECOVER-RC_Adult_GRU
No
Yes
Systolic Blood Pressure Intervention Trial (SPRINT-BioLINCC)
phs003483.v1.p1.c1
BioLINCC-BL_SPRINT_GRU
Yes
No
Surgical Treatment for Ischemic Heart Failure (STICH-BioLINCC)
phs003493.v1.p1.c1
BioLINCC-BL_STICH_GRU
Yes
No
Heart Failure Network Aldosterone Targeted Neurohormonal Combined with Natriuresis Therapy - (HFN ATHENA-BioLINCC)
phs003506.v1.p1.c1
BioLINCC-BL_HFN_ATHENA_GRU
Yes
No
Heart Failure Network - Effectiveness of Ultrafiltration in Treating People with Acute Decompensated Heart Failure and Cardiorenal Syndrome (HFN CARRESS - BioLINCC)
phs003510.v1.p1.c1
BioLINCC-BL_HFN_CARRESS_GRU
Yes
No
Sickle Cell Disease Natural History Data Resource (SCD NHDR)
phs003529.v1.p1.c1
CureSC-SCD_NHDR_GRU-IRB
No
No
Heart Failure Network - Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction (HFN NEAT-BioLINCC)
phs003548.v1.p1.c1
BioLINCC-BL_HFN-NEAT_GRU
Yes
No
Heart Failure Network - Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure (HFN RELAX-BioLINCC)
phs003565.v1.p1.c1
BioLINCC-BL_HFN-RELAX_GRU
Yes
No
Heart Failure Network - Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea (HFN ROSE-BioLINCC)
phs003589.v1.p1.c1
BioLINCC-BL_HFN-ROSE_GRU
Yes
No
Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION-BioLINCC)
phs003599.v1.p1.c1
BioLINCC-BL_HF-ACTION_HMB
Yes
No
Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION-BioLINCC)
phs003599.v1.p1.c2
BioLINCC-BL_HF-ACTION_HMB-NPU
Yes
No
Heart Failure Network: Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF (HFN INDIE-BioLINCC)
phs003667.v1.p1.c1
BioLINCC-BL_HFN-INDIE_GRU
Yes
No
CONNECTS Master Protocol for Clinical Trials targeting Macro- and Micro-Immuno-Thrombosis, Vascular Hyperinflammation, and Hypercoagulability and Renin-Angiotensin-Aldosterone System (RAAS) in Hospitalized Patients with COVID-19 (ACTIV-4 Host Tissue)
phs003708.v1.p1.c1
COVID19-ACTIV4_HostTissue_GRU
Yes
No
Acute Respiratory Distress Network (ARDSNet) Study 04 Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury (ALVEOLI-BioLINCC)
phs003714.v1.p1.c1
BioLINCC-BL_ARDSNet_ALVEOLI_GRU
Yes
No
Resuscitation Outcomes Consortium (ROC) Cardiac Epidemiologic Registry (Cardiac Epistry) Version 3 (ROC-Cardiac Epistry 3-BioLINCC)
phs003726.v1.p1.c1
BioLINCC-BL_ROC_Cardiac_Epistry_3_GRU
Yes
No
Beta-Blocker Evaluation in Survival Trial (BEST-BioLINCC)
phs003730.v1.p1.c1
BioLINCC-BL_BEST_GRU
Yes
No
Acute Respiratory Distress Network (ARDSNet) Studies 06 and 08 Prospective, Randomized, Multicenter Trial of Aerosolized Albuterol Versus Placebo for the Treatment of Acute Lung Injury (ALTA) (ARDSNet-ALTA-BioLINCC)
phs003743.v1.p1.c1
BioLINCC-BL_ARDSNet_ALTA_HMB-MDS
Yes
No
NHLBI TOPMed: Coronary Artery Risk Development in Young Adults (CARDIA)
phs001612.v3.p3.c1
topmed-CARDIA_HMB-IRB
No
Yes
NHLBI TOPMed: Coronary Artery Risk Development in Young Adults (CARDIA)
phs001612.v3.p3.c2
topmed-CARDIA_HMB-IRB-NPU
No
Yes
NHLBI TOPMed: Genetic Epidemiology of COPD (COPDGene)
phs000951.v6.p5.c2
topmed-COPDGene_DS-CS-RD
No
Yes
NHLBI TOPMed: Genetic Epidemiology of COPD (COPDGene)
phs000951.v6.p5.c1
topmed-COPDGene_HMB
No
Yes
NHLBI TOPMed: The Genetic Epidemiology of Asthma in Costa Rica
phs000988.v6.p1.c1
topmed-CRA_DS-ASTHMA-IRB-MDS-RD
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v4.p3.c1
topmed-IPF_DS-ILD-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v4.p3.c2
topmed-IPF_DS-LD-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v4.p3.c3
topmed-IPF_DS-PFIB-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v4.p3.c4
topmed-IPF_DS-PUL-ILD-IRB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v4.p3.c5
topmed-IPF_HMB-IRB-NPU
No
Yes
NHLBI TOPMed: Study of African Americans, Asthma, Genes and Environment (SAGE)
phs000921.v5.p2.c2
topmed-SAGE_DS-LD-IRB-COL
No
Yes
NHLBI TOPMed: Women's Health Initiative (WHI)
phs001237.v4.p2.c1
topmed-WHI_HMB-IRB
No
Yes
NHLBI TOPMed: Women's Health Initiative (WHI)
phs001237.v4.p2.c2
topmed-WHI_HMB-IRB-NPU
No
Yes
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Multi-Ethnic Study of Atherosclerosis (MESA)
phs003017.v1.p1.c1
COVID19-C4R_MESA_HMB
No
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Multi-Ethnic Study of Atherosclerosis (MESA)
phs003017.v1.p1.c2
COVID19-C4R_MESA_HMB-NPU
No
No
Acute Respiratory Distress Network (ARDSNet) Studies 01 and 03 Lower Versus Higher Tidal Volume, Ketoconazole Treatment and Lisofylline Treatment (ARMA/KARMA/LARMA) (ARDSNet-ARMA/KARMA/LARMA-BioLINCC)
phs003734.v1.p1.c1
BioLINCC-BL_ARDSNet_ARMA_KARMA_LARMA_GRU
Yes
No
ARDSNet 07-08: Randomized, Blinded, Placebo-Controlled, Multi-Center Trial of Omega-3 Fatty Acid, Gamma-Linolenic Acid, and Antioxidants in Acute Lung Injury or ARDS (OMEGA) (ARDSNet-Omega-BioLINCC)
phs003744.v1.p1.c1
BioLINCC-BL_ARDSNet_Omega_HMB-MDS
Yes
No
Acute Respiratory Distress Network (ARDSNet) Studies 10 and 12 Statins for Acutely Injured Lungs from Sepsis (SAILS) (ARDSNet-SAILS-BioLINCC)
phs003736.v1.p1.c1
BioLINCC-BL_ARDSNet_SAILS_HMB-MDS
Yes
No
Prevention and Early Treatment of Acute Lung Injury (PETAL) - Low Tidal Volume Universal Support Feasibility of Recruitment for Interventional Trial (LOTUS FRUIT) (PETAL-LOTUS FRUIT-BioLINCC)
phs003791.v1.p1.c1
BioLINCC-BL_PETAL_LOTUS_FRUIT_GRU
Yes
No
Resuscitation Outcomes Consortium (ROC) Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Ventricular Tachycardia (ALPS)
phs003784.v1.p1.c1
BioLINCC-BL_ROC_ALPS_GRU
Yes
No
Resuscitation Outcomes Consortium (ROC) Cardiac Epidemiologic Registry (Cardiac Epistry) Versions 1 and 2 (ROC-Cardiac Epistry 1 and 2-BioLINCC)
phs003803.v1.p1.c1
BioLINCC-BL_ROC_Cardiac_Epistry_1_2_GRU
Yes
No
Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT-BioLINCC)
phs003665.v1.p1.c1
BioLINCC-BL_TOPCAT_HMB-MDS
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Jackson Heart Study (JHS)
phs002907.v1.p1.c4
COVID19-C4R_JHS_DS-FDO-IRB
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Jackson Heart Study (JHS)
phs002907.v1.p1.c2
COVID19-C4R_JHS_DS-FDO-NPU-IRB
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Jackson Heart Study (JHS)
phs002907.v1.p1.c3
COVID19-C4R_JHS_HMB-IRB
Yes
No
Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Jackson Heart Study (JHS)
phs002907.v1.p1.c1
COVID19-C4R_JHS_HMB-NPU-IRB
Yes
No
Veterans Administration (VA) Million Veteran Program (MVP) Summary Results from Omics Studies
phs001672.v11.p1.c1
dbGaP-MVP_HMB-MDS
Yes
No
Multi-Ethnic Study of Atherosclerosis (Echocardiogram Image Repository)
phs003702.v1.p1.c1
imaging-img_MESA_ECHO_HMB
Yes
No
Multi-Ethnic Study of Atherosclerosis (Echocardiogram Image Repository)
phs003702.v1.p1.c2
imaging-img_MESA_ECHO_HMB-NPU
Yes
No
Incentives and Case Management to Improve Cardiac Care: Healthy Lifestyle Program (HeLP)
phs003737.v1.p1.c1
Individual_Study-UTMB_HeLP_GRU
Yes
No
Resuscitation Outcomes Consortium (ROC) Trauma Epidemiologic Registry (Trauma Epistry) (ROC-Trauma Epistry-BioLINCC)
phs003809.v1.p1.c1
BioLINCC-BL_ROC-Trauma_Epistry_GRU
Yes
No
BioLINCC The Women's Health Initiative (WHI)
phs003824.v1.c1
imaging-img_WHI_HMB
Yes
No
BioLINCC The Women's Health Initiative (WHI)
phs003824.v1.c2
imaging-img_WHI_HMB-NPU
Yes
No
The Jackson Heart Study (JHS)
phs003747.v1.p1.c1
imaging-img_JHS_HMB-IRB-NPU
Yes
No
The Jackson Heart Study (JHS)
phs003747.v1.p1.c2
imaging-img_JHS_DS-FDO-IRB-NPU
Yes
No
The Jackson Heart Study (JHS)
phs003747.v1.p1.c3
imaging-img_JHS_HMB-IRB
Yes
No
The Jackson Heart Study (JHS)
phs003747.v1.p1.c4
imaging-img_JHS_DS-FDO-IRB
Yes
No
Resuscitation Outcomes Consortium (ROC) Hypertonic Saline (HS) Trial Shock Study and Traumatic Brain Injury Study (TBI) (ROC-HS/TBI-BioLINCC)
phs003777.v1.p1.c1
BioLINCC-BL_ROC_HS_TBI-GRU
Yes
No
NHLBI TOPMed: Genomic Activities such as Whole Genome Sequencing and Related Phenotypes in the Framingham Heart Study
phs000974.v6.p5.c1
topmed-FHS_HMB-IRB-MDS
No
Yes
NHLBI TOPMed: Genomic Activities such as Whole Genome Sequencing and Related Phenotypes in the Framingham Heart Study
phs000974.v6.p5.c2
topmed-FHS_HMB-IRB-NPU-MDS
No
Yes
NHLBI TOPMed: MESA and MESA Family AA-CAC
phs001416.v4.p1.c1
topmed-MESA_HMB
No
Yes
NHLBI TOPMed: MESA and MESA Family AA-CAC
phs001416.v4.p1.c2
topmed-MESA_HMB-NPU
No
Yes
NHLBI TOPMed - NHGRI CCDG: Genes-Environments and Admixture in Latino Asthmatics (GALA II)
phs000920.v6.p4.c2
topmed-GALAII_DS-LD-IRB-COL
No
Yes
NHLBI TOPMed - NHGRI CCDG: Atherosclerosis Risk in Communities (ARIC)
phs001211.v5.p4.c1
topmed-ARIC_HMB-IRB-NPU-MDS
No
Yes
NHLBI TOPMed - NHGRI CCDG: Atherosclerosis Risk in Communities (ARIC)
phs001211.v5.p4.c2
topmed-ARIC_DS-CVD-IRB-NPU-MDS
No
Yes
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