2025-04-15 BDC Release Notes
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The 2025-04-15 release marks the 21st release for the NHLBI BioData Catalyst® (BDC) ecosystem. This release includes several new features (e.g., cloud cost estimator, PFB’s w/reference to raw files, and updates to cost monitoring workflows) along with documentation and tutorials (e.g., Publicly available coding examples for PIC-SURE on Terra) to help new users get started on the system. Please find more detail on the new features and user support materials in the sections below.
The 2025-04-15 data releases include the addition of Genes-Environments, Genomic Activities, Atherosclerosis Risk in Communities, Pulmonary Fibrosis, Molecular Atlas of Lung Development, Researching COVID to Enhance Recovery (RECOVER), Studies of Left Ventricular Dysfunction, Acute Respiratory Distress, COVID-19, Resuscitation Outcomes, Sedation Titration for Respiratory Failure, Study of Congestive Heart Failure, Prevention and Early Treatment of Acute Lung Injury. Please refer to the Data Releases section below for more information as well as the on the BDC website.
Velsera added cloud cost estimators for two additional workflows, samtools mpileup (tool used on BAM files in variant calling workflows), and samtools index (tool used to index BAM, CRAM or BGZIP-compressed SAM files). These calculators enable users to better estimate their cloud costs before running the analysis and incurring the charges. They bring the total number of tools and workflows with cost calculators to 10.
Gen3 team extended the data ingestion process to include the creation and persistence of PFBs containing references to each dataset's raw files. Gen3 Discovery Page was also extended to show these PFBs and allow them to be handed off to an analysis platform. This feature helps end users who want quick, easy access to the full dataset's original information by providing an interface in the existing Gen3 Discovery Page to see the PFBs. Data can be made available quickly without waiting for harmonized ingestion. Improves data provenance by keeping and making available the original, raw data.
Gen3 team created the ability for a user to obtain full, harmonized, study-level data as PFBs from the Discovery Page without having to generate them. This eliminates the time consuming, dynamic generation of cohorts when the user simply wants the whole dataset. The handoff of the ready available whole-study PFB can be easily done from the Discovery page to the analysis platform.
Terra has made several improvements for cost monitoring workflows. Terra now has the ability to show for workflows submitted after 3/3/25 and users can now test setting to avoid accidentally cost overruns.
Publicly available coding examples for PIC-SURE on Terra: The publicly available coding examples to get started exploring data and building participant-level cohorts with the PIC-SURE application programming interface has moved on Terra. These new workspaces contain updated code and documentation. Researchers can access the examples at the following links to Terra: , , and .
The table below highlights which studies were included in the 2025-04-15 data release.
NHLBI TOPMed - NHGRI CCDG: Genes-Environments and Admixture in Latino Asthmatics (GALA II)
phs000920.v6.p4.c2
topmed-GALAII_DS-LD-IRB-COL
No
Yes
NHLBI TOPMed: Genomic Activities such as Whole Genome Sequencing and Related Phenotypes in the Framingham Heart Study
phs000974.v6.p5.c1
topmed-FHS_HMB-IRB-MDS
No
Yes
NHLBI TOPMed: Genomic Activities such as Whole Genome Sequencing and Related Phenotypes in the Framingham Heart Study
phs000974.v6.p5.c2
topmed-FHS_HMB-IRB-NPU-MDS
No
Yes
NHLBI TOPMed - NHGRI CCDG: Atherosclerosis Risk in Communities (ARIC)
phs001211.v5.p4.c1
topmed-ARIC_HMB-IRB-NPU-MDS
No
Yes
NHLBI TOPMed - NHGRI CCDG: Atherosclerosis Risk in Communities (ARIC)
phs001211.v5.p4.c2
topmed-ARIC_DS-CVD-IRB-NPU-MDS
No
Yes
NHLBI TOPMed: MESA and MESA Family AA-CAC
phs001416.v4.p1.c1
topmed-MESA_HMB
No
Yes
NHLBI TOPMed: MESA and MESA Family AA-CAC
phs001416.v4.p1.c2
topmed-MESA_HMB-NPU
No
Yes
NHLBI TOPMed: Pulmonary Fibrosis Whole Genome Sequencing
phs001607.v4.p2.c6
topmed-IPF_DS-LD-IRB-COL-NPU
No
Yes
LungMAP: Molecular Atlas of Lung Development - Human Lung Tissue
phs001961.v3.p1.c1
LungMAP-MALD_GRU
No
Yes
Multi-Ethnic Study of Atherosclerosis (BioLINCC): BL_MESA
phs003288.v1.p1.c1
BioLINCC-BL_MESA_HMB
Yes
No
Multi-Ethnic Study of Atherosclerosis (BioLINCC): BL_MESA
phs003288.v1.p1.c2
BioLINCC-BL_MESA_HMB-NPU
Yes
No
Researching COVID to Enhance Recovery (RECOVER): RECOVER_Adult_6-24
phs003463.v2.p2.c1
RECOVER-RC_Adult_GRU
No
No
Studies of Left Ventricular Dysfunction (SOLVD)
phs003668.v1.p1.c1
BioLINCC-BL_SOLVD_GRU
Yes
No
Researching COVID to Enhance Recovery (RECOVER): Autopsy
phs003768.v1.p1.c1
RECOVER-RC_Autopsy_GRU
Yes
No
Acute Respiratory Distress Network (ARDSNet) Study 02 Late Steroid Rescue Study (LaSRS)
phs003769.v1.p1.c1
BioLINCC-BL_ARDSNet_LASRS_HMB-MDS
Yes
No
Resuscitation Outcomes Consortium (ROC) Hypertonic Saline Trial Shock Study (HS) and Traumatic Brain Injury Study (TBI)
phs003777.v1.p1.c1
BioLINCC-BL_ROC_HS_TBI_GRU
Yes
No
Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE)
phs003783.v1.p1.c1
BioLINCC-BL_RESTORE_GRU
Yes
No
Resuscitation Outcomes Consortium (ROC) Trauma Epidemiologic Registry (Trauma Epistry) (ROC-Trauma Epistry)
phs003809.v1.p1.c1
BioLINCC-BL_ROC-Trauma_Epistry_GRU
Yes
No
BioLINCC The Women's Health Initiative (WHI)
phs003824.v1.p1.c1
imaging-img_WHI_HMB
Yes
No
BioLINCC The Women's Health Initiative (WHI)
phs003824.v1.p1.c2
imaging-img_WHI_HMB-NPU
Yes
No
Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE)
phs003782.v1.p1.c1
BioLINCC-BL_ESCAPE_GRU
Yes
No
Prevention and Early Treatment of Acute Lung Injury Network – Reevaluation of Systemic Early Neuromuscular Blockade (PETAL ROSE)
phs003878.v1.p1.c1
BioLINCC-BL_PETAL_ROSE_HMB-MDS
Yes
No
Jackson Heart Study (JHS) BioLINCC
phs003740.v1.p1.c1
BioLINCC-BL_JHS_HMB-MDS
Yes
No
Jackson Heart Study (JHS) BioLINCC
phs003740.v1.p1.c2
BioLINCC-BL_JHS_HMB-NPU-MDS
Yes
No
Jackson Heart Study (JHS) BioLINCC
phs003740.v1.p1.c3
BioLINCC-BL_JHS_DS-CVD-MDS
Yes
No
Jackson Heart Study (JHS) BioLINCC
phs003740.v1.p1.c4
BioLINCC-BL_JHS_DS-CVD-NPU-MDS
Yes
No
COVID-19 ACTIV-4 ACUTE: A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic Strategies in Hospitalized Adults with COVID-19 (ACTIV4A)
phs002694.v4.p1.c1
COVID19-ACTIV4A_GRU
No
No
MIGen_ExS: BioImage Study
phs001058.v1.p1.c1
heartfailure-MiGEN_EXS_BIOIMAGE_DS-CVD
Yes
No
Rapid Early Action for Coronary Treatment (REACT)
phs003885.v1.p1.c1
BioLINCC-BL_REACT_GRU
Yes
No
Digitalis Investigation Group (DIG)
phs003872.v1.p1.c1
BioLINCC-BL_DIG_GRU
Yes
No
Prevention and Early Treatment of Acute Lung Injury Network – Vitamin D to Improve Outcomes by Leveraging Early Treatment (PETAL VIOLET)
phs003879.v1.p1.c1
BioLINCC-BL_PETAL_VIOLET_HMB-MDS
Yes
No
Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation on Helicopter Study (PROHS)(ROC-PROHS-BioLINCC)
phs003826.v1.p1.c1
BioLINCC-BL_ROC_PROHS_GRU
Yes
No
Sleep Heart Health Study (SHHS)
phs003637.v1.p1.c1
BioLINCC-BL_SHHS_NSRR_HMB-MDS
No
No
Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia
phs003844.v1.p1.c1
BioLINCC-BL_BEST_CLI_GRU
Yes
No
LungMAP: Molecular Atlas of Lung Development
phs001961.v3.p1.c1
LungMAP-MALD_GRU
No
No
ARDSnet and the iSPAAR Consortium: Genetic Studies
phs000631.v1.p1.c1
heartfailure-ARDSnet_gen_HMB
Yes
No
NHLBI TOPMed - NHGRI CCDG: Pakistan Risk of Myocardial Infarction Study (PROMIS)
phs001569.v1.p1.c1
topmed-PROMIS_GRU
Yes
No
NHLBI TOPMed - NHGRI CCDG: Groningen Genetics of Atrial Fibrillation (GGAF) Study
phs001725.v3.p1.c1
topmed-GGAF_GRU
No
Yes
Researching COVID to Enhance Recovery (RECOVER): Pediatrics
phs003461.v2.p2.c1
RECOVER-RC_Pediatrics_GRU
No
Yes
Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia: A Study in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide
phs003899.v1.p1.c1
BioLINCC-TOLSURF_GRU
Yes
No
Prevention and Early Treatment of Acute Lung Injury (PETAL) Acetaminophen in Sepsis: Targeted Therapy to Enhance Recovery
phs003900.v1.p1.c1
BioLINCC-PETAL_ASTER_HMB-MDS
Yes
No
Coronary Artery Risk Development in Young Adults (CARDIA) BioLINCC
phs003739.v1.p1.c1
BioLINCC-BL_CARDIA_HMB-MDS
Yes
No
Coronary Artery Risk Development in Young Adults (CARDIA) BioLINCC
phs003739.v1.p1.c2
BioLINCC-BL_CARDIA_HMB-NPU-MDS
Yes
No
Jackson Heart Study (JHS)
phs003747.v1.p1.c1
imaging-img_JHS_HMB-MDS
Yes
No
Jackson Heart Study (JHS)
phs003747.v1.p1.c2
imaging-img_JHS_HMB-NPU-MDS
Yes
No
Jackson Heart Study (JHS)
phs003747.v1.p1.c3
imaging-img_JHS_DS-CVD-MDS
Yes
No
Jackson Heart Study (JHS)
phs003747.v1.p1.c4
imaging-img_JHS_DS-CVD-NPU-MDS
Yes
No
Heart Failure Network: Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF (INDIE)
phs003804.v1.p1.c1
imaging-img_HFN_INDIE_GRU-IRB
Yes
No
Public Access Defibrillation Community Trial (PAD)
phs003858.v1.p1.c1
BioLINCC-BL_PAD_GRU
Yes
No
Resuscitation Outcomes Consortium Trial Of Continuous Compressions Versus Standard CPR In Patients With Out-Of-Hospital Cardiac Arrest
phs003901.v1.p1.c1
BioLINCC-BL_ROC_CCC_GRU
Yes
No
Consortium Pragmatic Trial of Airway Management in Out-of-Hospital Cardiac Arrest
phs003902.v1.p1.c1
BioLINCC-BL_ROC_PART_GRU
Yes
No
Lung Tissue Research Consortium
phs003913.v1.p1.c1
BioLINCC-BL_LTRC_DS-LD-MDS
Yes
No
SNPs and Extent of Atherosclerosis (SEA) Study
phs000349.v1.p1.c1
heartfailure-SEA_GRU
Yes
No
Researching COVID to Enhance Recovery (RECOVER): Adult
phs003463.v4.p3.c1
RECOVER-RC_Adult_GRU
No
Yes
Genetic Analysis of Limb Malformation Disorders: Miller Syndrome Sequencing Study (LMD-MS)
phs000244.v1.p1.c1
heartfailure-LMD-MS_GRU
Yes
No
Genetic Analysis of Limb Malformation Disorders: Freeman Sheldon Syndrome Exome Sequencing Study (LMD-FSS)
phs000204.v1.p1
heartfailure-LMD-FSS
Yes
No
Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis (PF-ILD Proteomics)
phs003954.v1.p1
BioLINCC-BL_PF_ILD
Yes
No
BLUE CORAL: Biology and Longitudinal Epidemiology of PETAL COVID-19 Observational Study Biology and Longitudinal Epidemiology of PETAL COVID-19 Observational Study (BLUE CORAL)
phs003419.v2.p1
COVID19-BLUE_CORAL
No
Yes
For detailed platform release notes please consult the following resources:
Gen3 release notes
Seven Bridges release notes