2025-07-15 BDC Release Notes
2025-07-15 BDC Ecosystem Release Notes
Introduction
The 2025-07-15 release marks the 22nd update to the BDC ecosystem. This release introduces several new features, including CellTypist, an upgraded GATK Variant, new training videos, support for PFB handoffs, and enhancements that enable workflows to run on the GCP Batch API. Additional details on these features and related user support materials are provided below.
The 2025-07-15 data releases include the addition of 63 new datasets. See the Data Releases section below for more information.
Significant new features
Velsera included CellTypist workflows and updated the GATK Variants to BDC Powered by Seven Bridges (BDC-Seven Bridges). CellTypist is an open-source tool developed for automated cell type annotation using single-cell RNA sequencing (scRNA-seq) data. The upgraded GATK Variants extracts specific fields from VCF or GVCF files and converts them into a tab-delimited table format, facilitating downstream analysis, visualization, and integration with spreadsheets and statistical tools. Both tools are available in the Public Apps Gallery to all BDC-Seven Bridges users. Additionally, Velsera has released a training video on using the new external connections panel on their YouTube channel. This feature makes it easier for users to connect to external data repositories like Synapse and CAVATICA, as well as linking to DRS servers to access data for analysis on BDC-Seven Bridges. YouTube Video linked here: BDC - Seven Bridges: Seamlessly Import External Datasets from Cavatica, Synapse & CGC
PIC-SURE enabled the handoff of PFBs to BDC-Seven Bridges. After creating a cohort of participants by selecting and filtering variables, investigators can now click the “Export to Seven Bridges” button to bring the participant-level data and associated data dictionary to a BDC-Seven Bridges project for analysis (see image below).
Terra has released upgrades so that all workflows will now run on GCP Batch API to address Google’s deprecation of the Life Science API. In addition, Terra has also released two new features to address cost management in the cloud: 1) Users now have the ability to set a cost threshold for a workflow to stop runaway costs from occurring, and 2) billing project owners now have the ability to enable GCP Quota Adjuster, which automatically raises quotas based on usage. Quota Adjuster is highly recommended for GCP Batch, as it supports most Compute Engine quotas, including Managed Instance Groups ("MIG").
Data Releases
The table below highlights which studies were included in the data releases in the months of May, June, and July 2025.
BioLINCC-BL_ARIC_HMB-NPU-MDS
phs003738.v1.p1.c1
New
BioLINCC-BL_BEST_COPD_GRU
phs004022.v1.p1.c1
New
BioLINCC-BL_ROC_PRIMED_GRU
phs003825.v2.p2.c1
New
heartfailure-PGRN_Afib_HMB
phs000439.v1.p1.c1
New
imaging-img_ARIC_HMB-IRB-NPU-MDS
phs003946.v1.p3.c1
New
Individual_Study-PATH_HHT_DS-HHT-IRB-PUB-COL
phs003948.v1.p1.c1
New
BioLINCC-BL_LRC_PS_GRU
phs003995.v1.p1.c1
New
BioLINCC-BL_SHHS_NSRR_HMB-MDS
phs003637.v1.p1.c1
Update (Other)
COVID19-ACTIV4A_GRU
phs002694.v4.p1.c1
Update (Other)
RECOVER-RC_Autopsy_GRU
phs003768.v2.p2.c1
Update (Version)
parent-FHS_HMB-IRB-MDS_
phs000007.v34.p15.c1
Update (Version)
parent-FHS_HMB-IRB-NPU-MDS_
phs000007.v34.p15.c2
Update (Version)
heartfailure-STAMPEED_MIGen_GRU
phs000294.v1.p1.c1
New
parent-PCGC_HMB_
phs001194.v4.p3.c1
Update (Version)
parent-PCGC_DS-CHD_
phs001194.v4.p3.c2
Update (Version)
topmed-PUSH_SCD_DS-SCD-IRB-PUB-COL
phs001682.v3.p1.c1
Update (Version)
BioLINCC-BL_ROC_CPR_GRU
phs003818.v1.p1.c1
New
BioLINCC-BL_PRHHP_GRU
phs003930.v1.p1.c1
New
imaging-img_HCSC-SOL_HMB-NPU
phs003963.v1.p1.c1
New
imaging-img_HCSC-SOL_HMB
phs003963.v1.p1.c2
New
BioLINCC-BL_IPPB_GRU
phs004010.v1.p1.c1
New
Individual_Study-INVESTED_GRU
phs004011.v1.p1.c1
New
BioLINCC-BL_LHS_GRU
phs004013.v1.p1.c1
New
DIR-Stressors_and_Health_Study_HMB-PUB-COL
phs004019.v1.p1.c1
New
BioLINCC-BL_PIOPED_GRU
phs004020.v1.p1.c1
New
BioLINCC-BL_ALLHAT_GRU
phs004021.v1.p1.c1
New
BioLINCC-BL_CONCERT_HF_GRU
phs004055.v1.p1.c1
New
parent-ARIC_HMB-IRB_
phs000280.v8.p2.c1
New
parent-ARIC_DS-CVD-IRB_
phs000280.v8.p2.c2
New
parent-CARDIA_HMB-IRB_
phs000285.v3.p2.c1
New
parent-CARDIA_HMB-IRB-NPU_
phs000285.v3.p2.c2
New
parent-JHS_HMB-IRB-NPU_
phs000286.v7.p2.c1
New
parent-JHS_DS-FDO-IRB-NPU_
phs000286.v7.p2.c2
New
parent-JHS_HMB-IRB_
phs000286.v7.p2.c3
New
parent-JHS_DS-FDO-IRB_
phs000286.v7.p2.c4
New
heartfailure-Fam_PAH_GRU
phs000354.v1.p1.c1
New
heartfailure-Fam_FAF_HMB
phs000362.v1.p1.c1
New
heartfailure-GENOA_GRU
phs000379.v1.p1.c1
New
heartfailure-PGRN_ACE_HMB
phs000438.v1.p1.c1
New
heartfailure-DrugRes_HTN_GRU
phs000442.v1.p1.c1
New
heartfailure-CAP_GRU
phs000481.v3.p2.c1
New
heartfailure-BEN_HMB
phs000507.v2.p2.c1
New
heartfailure-Fam_IB_GRU
phs000518.v1.p1.c1
New
heartfailure-Fam_DC_DS-FDC
phs000581.v1.p1.c1
New
heartfailure-KCNE1_TDP_HMB
phs000617.v1.p1.c1
New
heartfailure-Fam_CHD_HMB
phs000758.v1.p1.c1
New
heartfailure-MiGen_EXS_Ottawa_GRU
phs000806.v1.p1.c1
New
heartfailure-PGRN_DILQTS_GRU
phs000808.v1.p1.c1
New
heartfailure-MiGen_EXS_ItalAmer_GRU
phs000814.v1.p1.c1
New
heartfailure-Exome_Thrombo-Leuk_GRU
phs000873.v1.p1.c1
New
heartfailure-Twins_Asthma_GRU
phs000886.v1.p1.c1
New
heartfailure-MiGen_EXS_REGICOR_DS-CVD
phs000902.v1.p1.c1
New
heartfailure-MiGEN_EXS_PROMIS_GRU
phs000917.v1.p1.c1
New
heartfailure-BroadEOMI_exome_GRU
phs000936.v1.p1.c1
New
heartfailure-BroadEOMI_exome_DS-MI
phs000936.v1.p1.c2
New
heartfailure-BroadEOMI_exome_DS-CVD
phs000936.v1.p1.c3
New
heartfailure-PGRN_Cardio-Stat_HMB
phs000963.v1.p1.c1
New
heartfailure-MiGEN_EX_UL_DS-CVD
phs000990.v1.p1.c1
New
heartfailure-Endothelial_PAH_GRU
phs000998.v2.p1.c1
New
heartfailure-MiGEN_EXS_MDC_HMB-MDS
phs001101.v1.p1.c1
New
heartfailure-Globin_iPS_GRU
phs001212.v1.p1.c1
New
heartfailure-exRNA_healthy_HMB
phs001258.v2.p1.c1
New
topmed-CHIRAH_DS-ASTHMA-IRB-COL
phs001605.v3.p1.c2
Update (Version)
topmed-GCPD-A_DS-ASTHMA-GSO
phs001661.v4.p1.c1
Update (Version)
topmed-sumstats_GRU
phs001974.v8.p1.c1
New
heartfailure-REGARDS_GWAS_HMB-IRB
phs002719.v1.p1.c1
New
COVID19-C4R_CARDIA_HMB-IRB
phs003045.v2.p2.c1
New
COVID19-C4R_CARDIA_HMB-IRB-NPU
phs003045.v2.p2.c2
New
Individual_Study-PETAL_ROSE_ARDS_RNASeq_HMB
phs003929.v1.p1.c1
New
imaging-img_dMRI_VGC_GRU
phs004002.v1.p1.c1
New
BioLINCC-BL_NETT_GRU
phs004077.v1.p1.c1
New
BioLINCC-BL_PETAL_CLOVERS_HMB-MDS
phs004080.v1.p1.c1
New
BioLINCC-BL_STEP_IPF_GRU
phs004085.v1.p1.c1
New
Planned upcoming Data Releases For Q3
heartfailure-BroadEOMI_DS-CVD
phs000279.v2.p1.c1
New
heartfailure-LungExome_PAH_GRU
phs000290.v1.p1.c1
New
heartfailure-LHS-COPD_GRU
phs000291.v2.p1.c1
New
heartfailure-LHS_DS-HLB
phs000335.v3.p2.c1
New
heartfailure-Hypox_Ethiopia_GRU
phs000647.v1.p1.c1
New
BioLINCC-BL_HPP_GRU
phs003907.v1.p1.c1
New
Individual_Study-PRIME_AIR_HMB-MDS
phs003926.v1.p1.c1
New
BioLINCC-BL_LOTT_GRU
phs003933.v1.p1.c1
New
COVID19-ACTIV6_GRU
phs003941.v1.p1.c1
New
BioLINCC-BL_WRAP_IPF_GRU
phs003968.v1.p1.c1
New
imaging-img_dMRI_VGC_GRU
phs004002.v1.p1.c1
New
imaging-img_COPDGene_HMB
phs004023.v1.p1.c1
New
imaging-img_COPDGene_DS-CS
phs004023.v1.p1.c2
New
BioLINCC-BL_HIFI_GRU
phs004032.v1.p1.c1
New
Individual_Study-VDKA_DS-ASTHMA
phs004051.v1.p1.c1
New
Individual_Study-STAR_DS-ASTHMA
phs004052.v1.p1.c1
New
BioLINCC-BL_EPIC_GRU
phs004067.v1.p1.c1
New
BioLINCC-BL_ACE_IPF_GRU
phs004070.v1.p1.c1
New
BioLINCC-BL_Panther_IPF_GRU
phs004071.v1.p1.c1
New
BioLINCC-BL_PROP_GRU
phs004117.v1.p1.c1
New
BioLINCC-BL_FIRE_CORAL_HMB-MDS
phs004130.v1.p1.c1
New
BioLINCC-BL_ARDSNet_FACTT_HMB-MDS
phs004165.v1.p1.c1
New
BioLINCC-BL_ARDSNet_EDEN_HMB-MDS
phs004168.v1.p1.c1
New
BioLINCC-BL_HFN_LIFE_GRU
phs004171.v1.p1.c1
New
BioLINCC-BL_BHS_HMB-MDS
phs004173.v1.p1.c1
New
BioLINCC-BL_WHI_LILAC_GRU
phs004174.v1.p1.c1
New
imaging-img_ACCORD_GRU
phs003562.v1.p1.c1
Update (Other)
imaging-img_SPRINT_GRU
phs003566.v1.p1.c1
Update (Other)
imaging-img_MESA_ECG_HMB
phs003703.v1.p1.c1
Update (Other)
imaging-img_MESA_ECG_HMB-NPU
phs003703.v1.p1.c2
Update (Other)
dbGaP-PCGC_DS-CHD
phs000571.v7.p3.c2
parent-HCHS-SOL_HMB-NPU_
phs000810.v2.p2.c1
Update (Version)
parent-HCHS-SOL_HMB_
phs000810.v2.p2.c2
Update (Version)
topmed-CARDIA_HMB-IRB
phs001612.v3.p3.c1
Update (Version)
topmed-CARDIA_HMB-IRB-NPU
phs001612.v3.p3.c2
Update (Version)
topmed-LTRC_HMB-MDS
phs001662.v3.p1.c2
Update (Version)
BioLINCC-BL_SHHS_NSRR_HMB-MDS
phs003637.v2.p1.c1
Update (Version)
For detailed platform release notes please consult the following resources:
Gen3 release notes
Seven Bridges release notes
PIC-SURE release notes
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