2025-11-15 BDC Ecosystem Release Notes
This is the 23rd update to the BDC ecosystem.
Introduction
The 2025-11-15 release introduces several new features, including expanded data access, new interoperability tools, enhanced compute capabilities, and new bioinformatics workflows.
The 2025-11-15 data releases include the addition of 109 new datasets. See the Data Releases section for more information.
Significant New Features
The following new features this were released this quarter to improve the researcher experience.
BDC Powered by Seven Bridges (BDC-Seven Bridges)
SlicerJupyter, a new Data Studio environment for python-based interaction with 3D Slicer. The environment comes with several example notebooks explaining how to use the functionality for working with volumetric imaging data (for example, MRI, CT).
Expanded Data Access: We enabled full Sequence Read Archive (SRA) access via RAS Passport. This integration unlocks petabytes of controlled SRA data for researchers with valid Data Access Requests (DARs), improving data interoperability and access.
New Interoperability Tools: We published the PFB Unwrapper app, a new CWL tool that accepts .avro PFB files from Gen3, PIC-SURE, or AnVIL and creates a DRS manifest for streamlined import into BDC-Seven Bridges projects. This is a significant step in developing the PFB Importer v2 functionality to seamlessly execute the BDC Handoff Standard.
Enhanced Compute Capabilities: We deployed AWS 6th and 7th generation compute instance types, along with G5 and G6 GPU-enabled instance types for use in Data Studio sessions. These new instances offer researchers faster networking, better processing power, and improved hardware acceleration for machine learning applications.
New bioinformatics workflows: CellTypist, CellPhoneDB Toolkit, Nextflow-scRNA-Seq, and Nextflow-RNAvar.
BDC Powered by Terra (BDC-Terra)
New workspaces now use a more optimized format for data tables to increase performance and scalability.
Locking a workspace now makes the underlying bucket read-only while the workspace is locked.
More information about new features can be found in the Terra roadmap.
Data Releases
The table below highlights which studies were included in the data releases in the months of August, September, and October 2025.
BioLINCC-BL_ARIC_HMB-NPU-MDS
phs003738.v1.p1.c1
BioLINCC-BL_BEST_COPD_GRU
phs004022.v1.p1.c1
BioLINCC-BL_ROC_PRIMED_GRU
phs003825.v2.p2.c1
heartfailure-PGRN_Afib_HMB
phs000439.v1.p1.c1
imaging-img_ARIC_HMB-IRB-NPU-MDS
phs003946.v1.p3.c1
Individual_Study-PATH_HHT_DS-HHT-IRB-PUB-COL
phs003948.v1.p1.c1
BioLINCC-BL_LRC_PS_GRU
phs003995.v1.p1.c1
BioLINCC-BL_SHHS_NSRR_HMB-MDS
phs003637.v1.p1.c1
COVID19-ACTIV4A_GRU
phs002694.v4.p1.c1
RECOVER-RC_Autopsy_GRU
phs003768.v2.p2.c1
parent-FHS_HMB-IRB-MDS_
phs000007.v34.p15.c1
parent-FHS_HMB-IRB-NPU-MDS_
phs000007.v34.p15.c2
heartfailure-STAMPEED_MIGen_GRU
phs000294.v1.p1.c1
parent-PCGC_HMB_
phs001194.v4.p3.c1
parent-PCGC_DS-CHD_
phs001194.v4.p3.c2
topmed-PUSH_SCD_DS-SCD-IRB-PUB-COL
phs001682.v3.p1.c1
BioLINCC-BL_ROC_CPR_GRU
phs003818.v1.p1.c1
BioLINCC-BL_PRHHP_GRU
phs003930.v1.p1.c1
imaging-img_HCSC-SOL_HMB-NPU
phs003963.v1.p1.c1
imaging-img_HCSC-SOL_HMB
phs003963.v1.p1.c2
BioLINCC-BL_IPPB_GRU
phs004010.v1.p1.c1
Individual_Study-INVESTED_GRU
phs004011.v1.p1.c1
BioLINCC-BL_LHS_GRU
phs004013.v1.p1.c1
DIR-Stressors_and_Health_Study_HMB-PUB-COL
phs004019.v1.p1.c1
BioLINCC-BL_PIOPED_GRU
phs004020.v1.p1.c1
BioLINCC-BL_ALLHAT_GRU
phs004021.v1.p1.c1
BioLINCC-BL_CONCERT_HF_GRU
phs004055.v1.p1.c1
heartfailure-BroadEOMI_DS-CVD
phs000279.v2.p1.c1
parent-ARIC_HMB-IRB_
phs000280.v8.p2.c1
parent-ARIC_DS-CVD-IRB_
phs000280.v8.p2.c2
parent-CARDIA_HMB-IRB_
phs000285.v3.p2.c1
parent-CARDIA_HMB-IRB-NPU_
phs000285.v3.p2.c2
parent-JHS_HMB-IRB-NPU_
phs000286.v7.p2.c1
parent-JHS_DS-FDO-IRB-NPU_
phs000286.v7.p2.c2
parent-JHS_HMB-IRB_
phs000286.v7.p2.c3
parent-JHS_DS-FDO-IRB_
phs000286.v7.p2.c4
heartfailure-LungExome_PAH_GRU
phs000290.v1.p1.c1
heartfailure-LHS-COPD_GRU
phs000291.v2.p1.c1
heartfailure-Fam_PAH_GRU
phs000354.v1.p1.c1
heartfailure-Fam_FAF_HMB
phs000362.v1.p1.c1
heartfailure-GENOA_GRU
phs000379.v1.p1.c1
heartfailure-PGRN_ACE_HMB
phs000438.v1.p1.c1
heartfailure-DrugRes_HTN_GRU
phs000442.v1.p1.c1
heartfailure-CAP_GRU
phs000481.v3.p2.c1
heartfailure-BEN_HMB
phs000507.v2.p2.c1
heartfailure-Fam_IB_GRU
phs000518.v1.p1.c1
heartfailure-Fam_DC_DS-FDC
phs000581.v1.p1.c1
heartfailure-KCNE1_TDP_HMB
phs000617.v1.p1.c1
heartfailure-Hypox_Ethiopia_GRU
phs000647.v1.p1.c1
heartfailure-Fam_CHD_HMB
phs000758.v1.p1.c1
heartfailure-MiGen_EXS_Ottawa_GRU
phs000806.v1.p1.c1
heartfailure-PGRN_DILQTS_GRU
phs000808.v1.p1.c1
parent-HCHS-SOL_HMB-NPU_
phs000810.v2.p2.c1
parent-HCHS-SOL_HMB_
phs000810.v2.p2.c2
heartfailure-MiGen_EXS_ItalAmer_GRU
phs000814.v1.p1.c1
heartfailure-Exome_Thrombo-Leuk_GRU
phs000873.v1.p1.c1
heartfailure-Twins_Asthma_GRU
phs000886.v1.p1.c1
heartfailure-MiGen_EXS_REGICOR_DS-CVD
phs000902.v1.p1.c1
heartfailure-MiGEN_EXS_PROMIS_GRU
phs000917.v1.p1.c1
heartfailure-BroadEOMI_exome_GRU
phs000936.v1.p1.c1
heartfailure-BroadEOMI_exome_DS-MI
phs000936.v1.p1.c2
heartfailure-BroadEOMI_exome_DS-CVD
phs000936.v1.p1.c3
heartfailure-PGRN_Cardio-Stat_HMB
phs000963.v1.p1.c1
heartfailure-MiGEN_EX_UL_DS-CVD
phs000990.v1.p1.c1
heartfailure-Endothelial_PAH_GRU
phs000998.v2.p1.c1
heartfailure-MiGEN_EXS_MDC_HMB-MDS
phs001101.v1.p1.c1
heartfailure-Globin_iPS_GRU
phs001212.v1.p1.c1
heartfailure-exRNA_healthy_HMB
phs001258.v2.p1.c1
topmed-CHIRAH_DS-ASTHMA-IRB-COL
phs001605.v3.p1.c2
topmed-CARDIA_HMB-IRB
phs001612.v3.p3.c1
topmed-CARDIA_HMB-IRB-NPU
phs001612.v3.p3.c2
topmed-GCPD-A_DS-ASTHMA-GSO
phs001661.v4.p1.c1
topmed-LTRC_HMB-MDS
phs001662.v3.p1.c2
topmed-sumstats_GRU
phs001974.v8.p1.c1
heartfailure-REGARDS_GWAS_HMB-IRB
phs002719.v1.p1.c1
COVID19-C4R_CARDIA_HMB-IRB
phs003045.v2.p2.c1
COVID19-C4R_CARDIA_HMB-IRB-NPU
phs003045.v2.p2.c2
imaging-img_ACCORD_GRU
phs003562.v1.p1.c1
imaging-img_SPRINT_GRU
phs003566.v1.p1.c1
BioLINCC-BL_SHHS_NSRR_HMB-MDS
phs003637.v2.p1.c1
imaging-img_MESA_ECG_HMB
phs003703.v1.p1.c1
imaging-img_MESA_ECG_HMB-NPU
phs003703.v1.p1.c2
BioLINCC-BL_HPP_GRU
phs003907.v1.p1.c1
Individual_Study-PRIME_AIR_HMB-MDS
phs003926.v1.p1.c1
Individual_Study-PETAL_ROSE_ARDS_RNASeq_HMB
phs003929.v1.p1.c1
BioLINCC-BL_LOTT_GRU
phs003933.v1.p1.c1
BioLINCC-BL_WRAP_IPF_GRU
phs003968.v1.p1.c1
imaging-img_dMRI_VGC_GRU
phs004002.v1.p1.c1
imaging-img_COPDGene_HMB
phs004023.v1.p1.c1
imaging-img_COPDGene_DS-CS
phs004023.v1.p1.c2
BioLINCC-BL_HIFI_GRU
phs004032.v1.p1.c1
Individual_Study-VDKA_DS-ASTHMA
phs004051.v1.p1.c1
Individual_Study-STAR_DS-ASTHMA
phs004052.v1.p1.c1
BioLINCC-BL_EPIC_GRU
phs004067.v1.p1.c1
BioLINCC-BL_ACE_IPF_GRU
phs004070.v1.p1.c1
BioLINCC-BL_Panther_IPF_GRU
phs004071.v1.p1.c1
BioLINCC-BL_NETT_GRU
phs004077.v1.p1.c1
BioLINCC-BL_PETAL_CLOVERS_HMB-MDS
phs004080.v1.p1.c1
BioLINCC-BL_STEP_IPF_GRU
phs004085.v1.p1.c1
BioLINCC-BL_PROP_GRU
phs004117.v1.p1.c1
BioLINCC-BL_FIRE_CORAL_HMB-MDS
phs004130.v1.p1.c1
BioLINCC-BL_ARDSNet_FACTT_HMB-MDS
phs004165.v1.p1.c1
BioLINCC-BL_ARDSNet_EDEN_HMB-MDS
phs004168.v1.p1.c1
BioLINCC-BL_HFN_LIFE_GRU
phs004171.v1.p1.c1
BioLINCC-BL_BHS_HMB-MDS
phs004173.v1.p1.c1
BioLINCC-BL_WHI_LILAC_GRU
phs004174.v1.p1.c1
Upcoming Data Releases
The table below highlights studies that are planned for release in November and December.
CONNECTS_ACTIV4A_v4_r3
phs002694.v4.p1
dbGaP_MVP
phs001672.v13.p1
dbgap_CCF_AFIB
phs000820.v2.p1
dbGaP_FHS_parent
phs000007.v35.p16
TOPMed_Freeze10_LTRC
phs001662.v4.p2
Imaging-COPDGene-r2
phs004023.v1.p1
Imaging_MESA_ECG-r3
phs003703.v1.p1
Imaging_SPRINT-r3
phs003566.v1.p1
Imaging_ACCORD-r3
phs003562.v1.p1
dbGaP_COPDGene_Geno
phs000765.v3.p2
dbGaP_FHS_CHARGE-S
phs000651.v15.p16
dbgap_FHS_RNA_Brain
phs002611.v3.p16
dbGaP_FHS_GutMicro
phs002560.v3.p16
dbGaP_BRIDGET_FHS
phs002559.v3.p16
dbGap_ADSP_FHS
phs002558.v3.p16
dbGaP_T2D-GENES_FHS
phs001610.v6.p16
dbGaP_FHS_SHARe
phs000342.v23.p16
dbGaP_CCDG-ARIC
phs001536.v3.p2
dbGaP_ARIC_CARe
phs000557.v7.p2
TOPMed_Freeze10_HCHS_SOL
phs001395.v3.p2
TOPMed_Freeze10_CARE_TREXA
phs001732.v3.p1
For detailed platform release notes please consult the following resources:
Gen3 release notes
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