Requirements

To obtain access to BDC-PIC-SURE, you must have an NIH eRA Commons account. For instructions and to register an account, refer to the eRA website.

Login

After you have created an eRA Commons account, you can log in to BDC-PIC-SURE by navigating to and selecting to log in with eRA Commons. You will be directed to the NIH website to log in with your eRA Commons credentials. After signing in and accepting the terms of the agreement on the NIH RAS Information Sharing Consent page, allow the BDC-Gen3 service to manage your authorization.

Upon login, you will be directed to the Data Access Dashboard. This page provides a summary of PIC-SURE Authorized Access, PIC-SURE Open Access, and the studies you are authorized to access.

The BDC ecosystem hosts several datasets from the . To access the BioLINCC studies, you must request access through dbGaP even if you have authorization from BioLINCC.

BDC-PIC-SURE has integrated clinical and genomic data from a variety of heart, lung, blood, and sleep related datasets. These include NHLBI Trans-Omics for Precision Medicine (TOPMed) and TOPMed related studies, BioLINCC datasets, and COVID-19 datasets.

View a summary of the data you have access to by viewing the Data Access Table.

This table displays information about the study and associated data, including the full and abbreviated name of the study, study design and focus, the number of clinical variables, participants, and samples sequenced, additional information with helpful links, consent group information, and the dbGaP accession number (or phs number). You are also able to see which studies you are authorized to access in the Access column of the table. For information from dbGaP on submitting a data access request, refer to Tips for Preparing a Successful Data Access Request documentation. Note that studies with a sickle cell disease focus contain links to the Cure SCi Metadata Catalog for additional information.

You can also check the data you have access to by going to the page on the BDC website and clicking Check My Access.

The BDC ecosystem hosts several datasets from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. The PIC-SURE platform has integrated the clinical and genomic data from all studies listed in the Data Access Dashboard. Through the ingestion process, occasionally PIC-SURE will ingest phenotypic data for the TOPMed studies prior to the genomic data.

Harmonized Data (TOPMed Harmonized Clinical Variables)

There are limited amounts of harmonized data available at this time. The TOPMed Data Coordinating Center (DCC) curation team has identified 44 variables that are shared across 17 NHLBI studies and normalized the participant values for these variables.

The 44 harmonized variables available are listed in the table in Appendix 2. For more information on this initiative, you can view the or on the .

Table of Studies Included in the TOPMed Harmonized Dataset Available in PIC-SURE

The BDC ecosystem hosts several datasets from the NIH NHLBI Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies (CONNECTS) program. These COVID-19 related studies follow the guidelines for implementing common data elements (CDEs) and for de-identifying dates, ages, and free text fields. For more information about these efforts, you can view the CDE Manual and De-Identification Guidance documents on the CONNECTS COVID-19 Therapeutic Trial Common Data Elements webpage.

Table of COVID-19 Studies Included in the CONNECTS Program Available in PIC-SURE