This checklist is intended to help new users understand their obligations regarding access and permissions, which individual users are responsible for obtaining and maintaining.
Users create an eRA Commons Account through their institution's Office of Sponsored Research or equivalent. For more information, refer to Understanding eRA Commons Accounts.
About Data Access: dbGaP
Users who want to access a hosted controlled study on the BDC ecosystem must be approved for access to that study in the NIH Database of Genotypes and Phenotypes (). Therefore, users who want to access a hosted controlled study on the ecosystem must be approved for access to that study in dbGaP. For more information, see the . Note that obtaining these approvals can be a time-intensive process; failure to obtain them in a timely manner may delay data access.
Users have two options for obtaining dbGaP approval depending on whether they already are affiliated with a PI who has dbGaP access to the relevant data:
The BDC user has no affiliation with an existing dbGaP approved project. In this case the user needs to create their own dbGaP project and then submit a data access request (DAR) for approval by the NHLBI Data Access Committee (DAC). This process often takes 2-6 months depending on whether local IRB approval is required by the dataset the user is requesting, the amount of time it takes for local review of the dbGaP application by the user’s home institution and processing by the DAR committee. See thel or. Once a DAR is approved, it can take a week or longer for the approval to be reflected on BDC.
The BDC user is affiliated with an existing principal investigator, who already has an approved dbGaP application with existing DAR access (for example, the BDC user is a post-doctoral fellow in a PI’s lab). A principal investigator with dbGaP DAR access assigns the User as a “Downloader” in dbGaP. See. It can take about 24 hours for “Downloader” approval to be reflected on BDC.
Notes
DARs must be to maintain your data access permissions. If your permissions expire, you may lose access to hosted data in BDCatalyst during your renewal process.
A may be required as part of the DAR.
TOPMed
BDC hosts data from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. BDC users are not automatically onboarded as TOPMed investigators. BDC users who are not members of the TOPMed Consortium may apply for released data through the regular dbGaP Data Access Request process.
When conducting TOPMed-related research on BDC, members of the TOPMed consortium must follow the and associated processes; for example, operating within Working Groups.
For more information, refer to the following resources:
Information on TOPMed
(login required)
IRB
Users must ensure that IRB data use agreements (DUAs) are approved and maintained as they are enforced by the BDC ecosystem.
BDC
Refer to the BDC page to learn more about topics such as data privacy, access controls, and restrictions.
Use your eRA Commons account to review the data indexed by BDC to which you have access on the page. For more information, see .
If your data is not indexed, inform BDC team members during your onboarding meetings or by submitting a .