Appendix 2: Table of Harmonized Variables

cac_volume_1

Coronary artery calcium volume using CT scan(s) of coronary arteries

decimal

cubic millimeters

UMLS

cac_score_1

Coronary artery calcification (CAC) score using Agatston scoring of CT scan(s) of coronary arteries

decimal

UMLS

cimt_1

Common carotid intima-media thickness, calculated as the mean of two values: mean of multiple thickness estimates from the left far wall and from the right far wall.

decimal

mm

UMLS

cimt_2

Common carotid intima-media thickness, calculated as the mean of four values: maximum of multiple thickness estimates from the left far wall, left near wall, right far wall, and right near wall.

decimal

mm

UMLS

carotid_stenosis_1

Extent of narrowing of the carotid artery.

encoded

UMLS

0=None||1=1%-24%||2=25%-49%||3=50%-74%||4=75%-99%||5=100%

carotid_plaque_1

Presence or absence of carotid plaque.

encoded

UMLS

0=Plaque not present||1=Plaque present

height_baseline_1

Body height at baseline.

decimal

cm

UMLS

current_smoker_baseline_1

Indicates whether subject currently smokes cigarettes.

encoded

UMLS

0=Does not currently smoke cigarettes||1=Currently smokes cigarettes

weight_baseline_1

Body weight at baseline.

decimal

kg

UMLS

ever_smoker_baseline_1

Indicates whether subject ever regularly smoked cigarettes.

encoded

UMLS

0=Never a cigarette smoker||1=Current or former cigarette smoker

bmi_baseline_1

Body mass index calculated at baseline.

decimal

kg/m^2

UMLS

hemoglobin_mcnc_bld_1

Measurement of mass per volume, or mass concentration (mcnc), of hemoglobin in the blood (bld).

decimal

g / dL = grams per deciliter

UMLS

hematocrit_vfr_bld_1

Measurement of hematocrit, the fraction of volume (vfr) of blood (bld) that is composed of red blood cells.

decimal

% = percentage

UMLS

rbc_ncnc_bld_1

Count by volume, or number concentration (ncnc), of red blood cells in the blood (bld).

decimal

millions / microliter

UMLS

wbc_ncnc_bld_1

Count by volume, or number concentration (ncnc), of white blood cells in the blood (bld).

decimal

thousands / microliter

UMLS

basophil_ncnc_bld_1

Count by volume, or number concentration (ncnc), of basophils in the blood (bld).

decimal

thousands / microliter

UMLS

eosinophil_ncnc_bld_1

Count by volume, or number concentration (ncnc), of eosinophils in the blood (bld).

decimal

thousands / microliter

UMLS

neutrophil_ncnc_bld_1

Count by volume, or number concentration (ncnc), of neutrophils in the blood (bld).

decimal

thousands / microliter

UMLS

lymphocyte_ncnc_bld_1

Count by volume, or number concentration (ncnc), of lymphocytes in the blood (bld).

decimal

thousands / microliter

UMLS

monocyte_ncnc_bld_1

Count by volume, or number concentration (ncnc), of monocytes in the blood (bld).

decimal

thousands / microliter

UMLS

platelet_ncnc_bld_1

Count by volume, or number concentration (ncnc), of platelets in the blood (bld).

integer

thousands / microliter

UMLS

mch_entmass_rbc_1

Measurement of the average mass (entmass) of hemoglobin per red blood cell(rbc), known as mean corpuscular hemoglobin (MCH).

decimal

pg = picogram

UMLS

mchc_mcnc_rbc_1

Measurement of the mass concentration (mcnc) of hemoglobin in a given volume of packed red blood cells (rbc), known as mean corpuscular hemoglobin concentration (MCHC).

decimal

g /dL = grams per deciliter

UMLS

mcv_entvol_rbc_1

Measurement of the average volume (entvol) of red blood cells (rbc), known as mean corpuscular volume (MCV).

decimal

fL = femtoliter

UMLS

pmv_entvol_bld_1

Measurement of the mean volume (entvol) of platelets in the blood (bld), known as mean platelet volume (MPV or PMV).

decimal

fL = femtoliter

UMLS

rdw_ratio_rbc_1

Measurement of the ratio of variation in width to the mean width of the red blood cell (rbc) volume distribution curve taken at +/- 1 CV, known as red cell distribution width (RDW).

decimal

% = percentage

UMLS

bp_systolic_1

Resting systolic blood pressure from the upper arm in a clinical setting.

decimal

mmHg

UMLS

bp_diastolic_1

Resting diastolic blood pressure from the upper arm in a clinical setting.

decimal

mmHg

UMLS

antihypertensive_meds_1

Indicator for use of antihypertensive medication at the time of blood pressure measurement.

encoded

UMLS

0=Not taking antihypertensive medication||1=Taking antihypertensive medication

race_1

Harmonized race category of participant.

encoded

UMLS

AI_AN=American Indian_Alaskan Native or Native American||Asian=Asian||Black=Black or African American||HI_PI=Native Hawaiian or other Pacific Islander||Multiple=More than one race||Other=Other race||White=White or Caucasian

ethnicity_1

Indicator of Hispanic or Latino ethnicity.

encoded

UMLS

both=ethnicity component dbGaP variable values for a subject were inconsistent/contradictory (e.g. over multiple visits)||HL=Hispanic or Latino||notHL=not Hispanic or Latino

hispanic_subgroup_1

classification of Hispanic/Latino background for Hispanic/Latino subjects where country or region of origin information is available

encoded

UMLS

CentralAmerican=Central American||CostaRican=from Costa Rica||Cuban=Cuban||Dominican=Dominican||Mexican=Mexican||PuertoRican=Puerto Rican||SouthAmerican=South American

annotated_sex_1

Subject sex, as recorded by the study.

encoded

UMLS

female=Female||male=Male

geographic_site_1

Recruitment/field center, baseline clinic, or geographic region.

encoded

UMLS

subcohort_1

A distinct subgroup within a study, generally indicating subjects who share similar characteristics due to study design. Subjects may belong to only one subcohort.

encoded

UMLS

lipid_lowering_medication_1

Indicates whether participant was taking any lipid-lowering medication at blood draw to measure lipids phenotypes

encoded

UMLS

0=Participant was not taking lipid-lowering medication||1=Participant was taking lipid-lowering medication.

fasting_lipids_1

Indicates whether participant fasted for at least eight hours prior to blood draw to measure lipids phenotypes.

encoded

UMLS

0=Participant did not fast_or fasted for fewer than eight hours prior to measurement of lipids phenotypes.||1=Participant fasted for at least eight hours prior to measurement of lipids phenotypes.

total_cholesterol_1

Blood mass concentration of total cholesterol

decimal

mg/dL

UMLS

triglycerides_1

Blood mass concentration of triglycerides

decimal

mg/dL

UMLS

hdl_1

Blood mass concentration of high-density lipoprotein cholesterol

decimal

mg/dL

UMLS

ldl_1

Blood mass concentration of low-density lipoprotein cholesterol

decimal

mg/dL

UMLS

vte_prior_history_1

An indicator of whether a subject had a venous thromboembolism (VTE) event prior to the start of the medical review process (including self-reported events).

encoded

UMLS

0=did not have prior VTE event||1=had prior VTE event

vte_case_status_1

An indicator of whether a subject experienced a venous thromboembolism event (VTE) that was verified by adjudication or by medical professionals.

encoded

UMLS

0=Not known to ever have a VTE event_either self-reported or from medical records||1=Experienced a VTE event as verified by adjudication or by medical professionals

age_at_*

For each phenotypic value for a given subject, an associated age at measurement is provided.

decimal

years

See TOPMed Harmonization Strategies for more information.

unit_*

For each harmonized variable, a paired “unit_variable” is provided, whose value indicates where in the documentation to look to find the set of component variables and the algorithm used to harmonize those variables.

encoded

See TOPMed Harmonization Strategies for more information.

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