# Appendix 2: Table of Harmonized Variables | cac\_volume\_1 | Coronary artery calcium volume using CT scan(s) of coronary arteries | decimal | cubic millimeters | UMLS | | | ------------------------------ | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ------- | ---------------------------- | ---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | cac\_score\_1 | Coronary artery calcification (CAC) score using Agatston scoring of CT scan(s) of coronary arteries | decimal | | UMLS | | | cimt\_1 | Common carotid intima-media thickness, calculated as the mean of two values: mean of multiple thickness estimates from the left far wall and from the right far wall. | decimal | mm | UMLS | | | cimt\_2 | Common carotid intima-media thickness, calculated as the mean of four values: maximum of multiple thickness estimates from the left far wall, left near wall, right far wall, and right near wall. | decimal | mm | UMLS | | | carotid\_stenosis\_1 | Extent of narrowing of the carotid artery. | encoded | | UMLS | 0=None\|\|1=1%-24%\|\|2=25%-49%\|\|3=50%-74%\|\|4=75%-99%\|\|5=100% | | carotid\_plaque\_1 | Presence or absence of carotid plaque. | encoded | | UMLS | 0=Plaque not present\|\|1=Plaque present | | height\_baseline\_1 | Body height at baseline. | decimal | cm | UMLS | | | current\_smoker\_baseline\_1 | Indicates whether subject currently smokes cigarettes. | encoded | | UMLS | 0=Does not currently smoke cigarettes\|\|1=Currently smokes cigarettes | | weight\_baseline\_1 | Body weight at baseline. | decimal | kg | UMLS | | | ever\_smoker\_baseline\_1 | Indicates whether subject ever regularly smoked cigarettes. | encoded | | UMLS | 0=Never a cigarette smoker\|\|1=Current or former cigarette smoker | | bmi\_baseline\_1 | Body mass index calculated at baseline. | decimal | kg/m^2 | UMLS | | | hemoglobin\_mcnc\_bld\_1 | Measurement of mass per volume, or mass concentration (mcnc), of hemoglobin in the blood (bld). | decimal | g / dL = grams per deciliter | UMLS | | | hematocrit\_vfr\_bld\_1 | Measurement of hematocrit, the fraction of volume (vfr) of blood (bld) that is composed of red blood cells. | decimal | % = percentage | UMLS | | | rbc\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of red blood cells in the blood (bld). | decimal | millions / microliter | UMLS | | | wbc\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of white blood cells in the blood (bld). | decimal | thousands / microliter | UMLS | | | basophil\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of basophils in the blood (bld). | decimal | thousands / microliter | UMLS | | | eosinophil\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of eosinophils in the blood (bld). | decimal | thousands / microliter | UMLS | | | neutrophil\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of neutrophils in the blood (bld). | decimal | thousands / microliter | UMLS | | | lymphocyte\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of lymphocytes in the blood (bld). | decimal | thousands / microliter | UMLS | | | monocyte\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of monocytes in the blood (bld). | decimal | thousands / microliter | UMLS | | | platelet\_ncnc\_bld\_1 | Count by volume, or number concentration (ncnc), of platelets in the blood (bld). | integer | thousands / microliter | UMLS | | | mch\_entmass\_rbc\_1 | Measurement of the average mass (entmass) of hemoglobin per red blood cell(rbc), known as mean corpuscular hemoglobin (MCH). | decimal | pg = picogram | UMLS | | | mchc\_mcnc\_rbc\_1 | Measurement of the mass concentration (mcnc) of hemoglobin in a given volume of packed red blood cells (rbc), known as mean corpuscular hemoglobin concentration (MCHC). | decimal | g /dL = grams per deciliter | UMLS | | | mcv\_entvol\_rbc\_1 | Measurement of the average volume (entvol) of red blood cells (rbc), known as mean corpuscular volume (MCV). | decimal | fL = femtoliter | UMLS | | | pmv\_entvol\_bld\_1 | Measurement of the mean volume (entvol) of platelets in the blood (bld), known as mean platelet volume (MPV or PMV). | decimal | fL = femtoliter | UMLS | | | rdw\_ratio\_rbc\_1 | Measurement of the ratio of variation in width to the mean width of the red blood cell (rbc) volume distribution curve taken at +/- 1 CV, known as red cell distribution width (RDW). | decimal | % = percentage | UMLS | | | bp\_systolic\_1 | Resting systolic blood pressure from the upper arm in a clinical setting. | decimal | mmHg | UMLS | | | bp\_diastolic\_1 | Resting diastolic blood pressure from the upper arm in a clinical setting. | decimal | mmHg | UMLS | | | antihypertensive\_meds\_1 | Indicator for use of antihypertensive medication at the time of blood pressure measurement. | encoded | | UMLS | 0=Not taking antihypertensive medication\|\|1=Taking antihypertensive medication | | race\_1 | Harmonized race category of participant. | encoded | | UMLS | AI\_AN=American Indian\_Alaskan Native or Native American\|\|Asian=Asian\|\|Black=Black or African American\|\|HI\_PI=Native Hawaiian or other Pacific Islander\|\|Multiple=More than one race\|\|Other=Other race\|\|White=White or Caucasian | | ethnicity\_1 | Indicator of Hispanic or Latino ethnicity. | encoded | | UMLS | both=ethnicity component dbGaP variable values for a subject were inconsistent/contradictory (e.g. over multiple visits)\|\|HL=Hispanic or Latino\|\|notHL=not Hispanic or Latino | | hispanic\_subgroup\_1 | classification of Hispanic/Latino background for Hispanic/Latino subjects where country or region of origin information is available | encoded | | UMLS | CentralAmerican=Central American\|\|CostaRican=from Costa Rica\|\|Cuban=Cuban\|\|Dominican=Dominican\|\|Mexican=Mexican\|\|PuertoRican=Puerto Rican\|\|SouthAmerican=South American | | annotated\_sex\_1 | Subject sex, as recorded by the study. | encoded | | UMLS | female=Female\|\|male=Male | | geographic\_site\_1 | Recruitment/field center, baseline clinic, or geographic region. | encoded | | UMLS | | | subcohort\_1 | A distinct subgroup within a study, generally indicating subjects who share similar characteristics due to study design. Subjects may belong to only one subcohort. | encoded | | UMLS | | | lipid\_lowering\_medication\_1 | Indicates whether participant was taking any lipid-lowering medication at blood draw to measure lipids phenotypes | encoded | | UMLS | 0=Participant was not taking lipid-lowering medication\|\|1=Participant was taking lipid-lowering medication. | | fasting\_lipids\_1 | Indicates whether participant fasted for at least eight hours prior to blood draw to measure lipids phenotypes. | encoded | | UMLS | 0=Participant did not fast\_or fasted for fewer than eight hours prior to measurement of lipids phenotypes.\|\|1=Participant fasted for at least eight hours prior to measurement of lipids phenotypes. | | total\_cholesterol\_1 | Blood mass concentration of total cholesterol | decimal | mg/dL | UMLS | | | triglycerides\_1 | Blood mass concentration of triglycerides | decimal | mg/dL | UMLS | | | hdl\_1 | Blood mass concentration of high-density lipoprotein cholesterol | decimal | mg/dL | UMLS | | | ldl\_1 | Blood mass concentration of low-density lipoprotein cholesterol | decimal | mg/dL | UMLS | | | vte\_prior\_history\_1 | An indicator of whether a subject had a venous thromboembolism (VTE) event prior to the start of the medical review process (including self-reported events). | encoded | | UMLS | 0=did not have prior VTE event\|\|1=had prior VTE event | | vte\_case\_status\_1 | An indicator of whether a subject experienced a venous thromboembolism event (VTE) that was verified by adjudication or by medical professionals. | encoded | | UMLS | 0=Not known to ever have a VTE event\_either self-reported or from medical records\|\|1=Experienced a VTE event as verified by adjudication or by medical professionals | | age\_at\_\* | For each phenotypic value for a given subject, an associated age at measurement is provided. | decimal | years | | See [TOPMed Harmonization Strategies ](https://topmed.nhlbi.nih.gov/dcc-harmonized-phenotypes)for more information. | | unit\_\* | For each harmonized variable, a paired “unit\_variable” is provided, whose value indicates where in the documentation to look to find the set of component variables and the algorithm used to harmonize those variables. | encoded | | | See [TOPMed Harmonization Strategies ](https://topmed.nhlbi.nih.gov/dcc-harmonized-phenotypes)for more information. |